Adverse effects of pertussis and rubella vaccines : a report of the Committee to Review the Adverse Consequences of Pertussis and Rubella Vaccines / Christopher P. Howson, Cynthia J. Howe, and Harvey V. Fineberg, editors.

Format:

Book

Author/Creator:

Institute of Medicine (U.S.). Committee to Review the Adverse Consequences of Pertussis and Rubella Vaccines.

Contributor:

Howson, Christopher Paul.

Howe, Cynthia J.

Fineberg, Harvey V.

Language:

English

Subjects (All):

Pertussis vaccines--Side effects--Congresses.

Pertussis vaccines.

Rubella vaccines--Side effects--Congresses.

Rubella vaccines.

Whooping cough--Vaccination--Complications--Congresses.

Whooping cough.

Rubella--Vaccination--Complications--Congresses.

Rubella.

Pertussis Vaccine--adverse effects.

Rubella Vaccine--adverse effects.

Medical Subjects:

Pertussis Vaccine--adverse effects.

Rubella Vaccine--adverse effects.

Physical Description:

1 online resource (xii, 367 pages) : illustrations

Edition:

1st ed.

Place of Publication:

Washington, D.C. : National Academy Press, 1991.

Language Note:

English

Summary:

Some evidence suggests that vaccination against pertussis and rubella is, in a small number of cases, associated with increased risk of serious illness. This book offers an assessment of the risk of illness following immunization with vaccines against pertussis and rubella. It is useful for public health officials, pediatricians, and parents.

Contents:

Adverse Effects of Pertussis and Rubella Vaccines

Copyright

Preface

Acknowledgments

Contents

Adverse Effects of PERTUSSIS and RUBELLA Vaccines

1 Executive Summary

METHODOLOGIC CONSIDERATIONS IN EVALUATING THE EVIDENCE

SUMMARY AND CONCLUSIONS

RESEARCH NEEDS

2 Histories of Pertussis and Rubella Vaccines

PERTUSSIS VACCINES

Epidemiology of Whooping Cough

Clinical Description

Diagnosis

Complications

Descriptive Epidemiology

Nature of the Causative Organism, B. pertussis

Major Milestones in the Development of Pertussis Vaccines

Whole-Cell Vaccines

Acellular Vaccines

Brief History of the Controversy Pertaining to Adverse Events Following Pertussis Vaccination

RUBELLA VACCINES

Epidemiology of the Disease Rubella

Nature of the Rubella Virus

Major Milestones in the Development of Rubella Vaccines

Brief History of the Controversy Pertaining to Adverse Events Following Rubella Vaccination

REFERENCES

3 Methodologic Considerations in Evaluating the Evidence

THE NATURE OF THE EVIDENCE

QUESTIONS TO BE ADDRESSED

(1) Can vaccine cause the adverse event?

(2) How frequently does vaccine cause the event?

(3) Did vaccination cause a particular case of the adverse event?

THE BURDEN OF PROOF

CATEGORIES OF EVIDENCE

Experiments in Humans

Randomized Controlled Trials

Other Experimental Studies

Experiments in Animals: Animal Models

Controlled Epidemiologic Studies (Observational)

Cohort Studies

Case-Comparison Studies

Other Controlled Studies

Case Reports and Case Series

Searching for Patterns

Historical Comparisons

Causation of the Individual Case

Monitoring System for Adverse Events Following Immunization

ASSESSMENT OF THE EVIDENCE.

Evaluation of Single Studies

Integration of the Collective Results

Meta-Analysis

Considerations in Inferring Causality

THE NATURE OF THE CONCLUSIONS

Quantitation

Resolution

Uncertainty and Confidence

Quality

Comprehensiveness

Neutrality

Judgment

SUMMARY OF THE EVIDENCE

4 Evidence Concerning Pertussis Vaccines and Central Nervous System Disorders, Including Infantile...

INFANTILE SPASMS

History of Suspected Association with Pertussis Vaccines

Evidence from Studies in Humans

Controlled Epidemiologic Studies

Summary

Conclusion

HYPSARRHYTHMIA

ASEPTIC MENINGITIS

ENCEPHALOPATHY

Encephalopathy Following Whooping Cough

Pathology

Studies in Defined Populations

The National Childhood Encephalopathy Study

Other Controlled Studies in Humans

Evidence from Studies in Animals

Aluminum Salts

5 Evidence Concerning Pertussis Vaccines and Deaths Classified as Sudden Infant Death Syndrome

CLINICAL DESCRIPTION, DIAGNOSIS, AND PATHOLOGY

DESCRIPTIVE EPIDEMIOLOGY.

HISTORY OF SUSPECTED ASSOCIATION WITH PERTUSSIS VACCINES

EVIDENCE FROM STUDIES IN HUMANS

SUMMARY

CONCLUSION

6 Evidence Concerning Pertussis Vaccines and Other Illnesses and Conditions

ANAPHYLAXIS

Clinical Description and Pathologic Aspects

Case Reports and Controlled Epidemiologic Studies

Endotoxin

AUTISM

ERYTHEMA MULTIFORME OR OTHER RASH

Case Reports

GUILLAIN-BARRÉ SYNDROME (POLYNEUROPATHY)

PERIPHERAL MONONEUROPATHY

HEMOLYTIC ANEMIA

JUVENILE DIABETES

Controlled Epidemiologic Study

Case Report

LEARNING DISABILITIES AND HYPERACTIVITY

Learning Disability, Reading Disability, and Dyslexia

Hyperactivity, Hyperkinesis, and Attention Deficit Disorder

Summary.

Conclusion

PROTRACTED INCONSOLABLE CRYING AND SCREAMING

Conclusions

REYE SYNDROME

SHOCK AND ''UNUSUAL SHOCK-LIKE STATE" WITH HYPOTONICITY, HYPORESPONSIVENESS, AND SHORT-LIVED CONVULS ...

THROMBOCYTOPENIA

7 Evidence Concerning Rubella Vaccines and Arthritis, Radiculoneuritis, and Thrombocytopenic Purpura

ARTHRITIS

History of an Association with Rubella Vaccines

Acute Arthropathy and Arthritis

Chronic Arthritis

Possible Mechanisms

RADICULONEURITIS AND OTHER NEUROPATHIES

THROMBOCYTOPENIC PURPURA

Afterword on Research Needs

Bibliography

Glossary of Terms B

Appendixes.

A Strategies For Gathering Information: Adverse Effects of Pertussis and Rubella Vaccines

LITERATURE SEARCHES

Electronic Data Bases

OTHER SOURCES

Reference Lists

Presentations

Public Meeting (January 10, 1990)

Workshop (May 14, 1990)

Committee Meeting (May 15, 1990)

Additional Individuals and Organizations Who Provided Information

Review of Interim Bibliography

ABSTRACTION OF DATA FROM CASE REPORTS, CASE SERIES, AND CONTROLLED STUDIES

Rationale

Procedures for Abstraction and Adjudication of Study Data

B Pertussis and Rubella Vaccines: A Brief Chronology

C Animal Models for the Study of Whooping Cough and the Testing of Vaccine Materials

ANIMAL MODELS FOR THE STUDY OF WHOOPING COUGH

STANDARDIZED ANIMAL TESTS OF VACCINE MATERIALS

D Technical Details of Power Calculations and Meta-Analyses

POWER CALCULATIONS

META-ANALYSES

Formal Analysis

Informal Analysis

E Possible Involvement of Aluminum Salts in Erythema Multiforme, Encephalopathy, or Other Adverse E ...

F Committee and Staff Biographies

COMMITTEE

STAFF

Index.

Notes:

Bibliographic Level Mode of Issuance: Monograph

Includes bibliographical references (p. 208-282) and index.

Other Format:

Print version: Institute of Medicine (U.S.). Committee to Review the Adverse Consequences of Pertussis and Rubella Vaccines. Adverse effects of pertussis and rubella vaccines.

ISBN:

9786610203703

9781280203701

1280203706

9780309555975

0309555973

9780585034331

0585034338

OCLC:

42330229