Selected issues in risk assessment / Safe Drinking Water Committee, Board on Toxicology and Environmental Health Hazards, Assembly of Life Sciences, National Research Council.

Format:

Book

Author/Creator:

National Research Council (U.S.)

Series:

Drinking water and health ; v.9

Language:

English

Subjects (All):

Drinking water--Contamination.

Drinking water.

Drinking water--Health aspects--United States.

Physical Description:

1 online resource (xiv, 268 pages) : illustrations

Edition:

1st ed.

Place of Publication:

Washington, D.C. : National Academy Press, 1989.

Language Note:

English

Summary:

Providing an overview of DNA adducts and their effects on health, this title explores the techniques in use for detecting them and offers an outlook on toxicity testing. It also explores the issues surrounding multiple-chemical exposure from drinking water and reviews options for grouping compounds so their toxicity in mixtures can be assessed.

Contents:

1 Front Matter; 2 Part I: DNA Adducts; 3 Executive Summary; 4 1 Biologic Significance of DNA Adducts and Protein Adducts; 5 2 DNA-Adduct Technology; 6 3 Conclusions and Recommendations; 7 Appendix A: Drinking Water Contaminant Candidates for Development of Baseline Data on Formation of DNA Adducts; 8 Glossary; 9 Biographical Sketches; 10 Part II: Mixtures; 11 Executive Summary; 12 1 Introduction; 13 2 Pharmacokinetics and the Risk Assessment of Drinking Water Contaminants; 14 3 Risk Assessment of Mixtures of Systemic Toxicants in Drinking Water; 15 4 Assessment of Exposure to Organophosphorus Compounds, Carbamates, and Volatile Organic Chemicals; 16 5 Acetylcholinesterase Inhibitors: Case Study of Mixtures of Contaminates with Similar Biologic Effects; 17 6 Volatile Organic Compounds (VOCs): Risk Assessment of Mixtures of Potentially Carcinogenic Chemicals; 18 7 Conclusions and Recommendations for Research; 19 Appendix A: An Approach for Risk Assessment of Volatile Organic Chemicals in Drinking Water That Uses Experimental Inhalation Data and a Physiologically Based Pharmacokinetic Model; 20 Appendix B: A Model Illustrating Synergism; 21 Appendix C: Models of Response: Dose Additivity and Response Additivity; 22 Biographical Sketches; 23 Part III: Cumulative Index; 24 Index

Notes:

Bibliographic Level Mode of Issuance: Monograph

ISBN:

9786610214709

9781280214707

1280214708

9780309542920

0309542928

9780585085043

0585085048

OCLC:

666937346