Radiation dose reconstruction for epidemiologic uses / Committee on an Assessment of CDC Radiation Studies, Board on Radiation Effects Research, Commission on Life Sciences, National Research Council.

Format:

Book

Contributor:

National Research Council (U.S.). Committee on an Assessment of CDC Radiation Studies.

Language:

English

Subjects (All):

Radiation injuries--Epidemiology--Statistical methods.

Radiation injuries.

Radiation dosimetry.

Radiation Injuries--epidemiology.

Dose-Response Relationship, Radiation.

Radioactive Hazard Release.

Radiometry.

Medical Subjects:

Radiation Injuries--epidemiology.

Dose-Response Relationship, Radiation.

Radioactive Hazard Release.

Radiometry.

Physical Description:

1 online resource (150 p.)

Edition:

1st ed.

Place of Publication:

Washington, DC : National Academy Press, 1995.

Language Note:

English

Summary:

Growing public concern about releases of radiation into the environment has focused attention on the measurement of exposure of people living near nuclear weapons production facilities or in areas affected by accidental releases of radiation. Radiation-Dose Reconstruction for Epidemiologic Uses responds to the need for criteria for dose reconstruction studies, particularly if the doses are to be useful in epidemiology. This book provides specific and practical recommendations for whether, when, and how studies should be conducted, with an emphasis on public participation. Based on the expertise of scientists involved in dozens of dose reconstruction projects, this volume Provides an overview of the basic requirements and technical aspects of dose reconstruction. Presents lessons to be learned from dose reconstructions after Chernobyl, Three Mile Island, and elsewhere. Explores the potential benefits and limitations of biological markers. Discusses how to establish the "source term"--that is, to determine what was released. Explores methods for identifying the environmental pathways by which radiation reaches the body. Offers details on three major categories of dose assessment.

Contents:

Radiation Dose Reconstruction for Epidemiologic Uses

Copyright

Preface

Contents

Executive Summary

1 Background

2 Introduction

ELEMENTS OF DOSE RECONSTRUCTION

TECHNICAL ASPECTS OF DOSE RECONSTRUCTION

STRUCTURE OF A SCOPING STUDY

PUBLIC INVOLVEMENT

SUMMARY AND RECOMMENDATIONS

NOTE

3 Estimating and Confirming The Source Term

APPROACH TO SOURCE TERM ANALYSIS

DATA REQUIREMENTS FOR SOURCE TERM ANALYSIS

EPISODIC RELEASES

SOURCES OF INFORMATION

BIAS AND UNCERTAINTY IN RELEASE ESTIMATES

GAPS IN RELEASE DATA

4 Environmental Pathways

TRANSPORT OF RADIONUCLIDES AND OTHER CONTAMINANTS

Direct Releases to the Atmosphere

Direct Releases to the Hydrosphere

FURTHER CONSIDERATIONS

Appropriate Use of Mathematical Models

Uncertainty Analysis

5 Radiation Dose Assessment

SOURCES OF EXPOSURE

Ambient Exposure

Inhalation Exposure

Ingestion Exposure

POTENTIAL CONSEQUENCES OF RADIATION EXPOSURE

PRELIMINARY DOSE ASSESSMENT

COMPREHENSIVE DOSE ASSESSMENT

INDIVIDUAL DOSE ASSESSMENT

UNCERTAINTY

6 Biologic Dosimetry and Biologic Markers

MARKERS OF EXPOSURE AND DOSE

Cytogenetic Markers

Genetic or Molecular Markers

Combined Biologic-Maker Assays

MARKERS OF EFFECT

MARKERS OF SUSCEPTIBILITY

MARKERS IN RETROSPECTIVE DOSIMETRY

MARKERS IN EPIDEMIOLOGY

7 Epidemiologic Considerations

QUANTITATIVE RISK ASSESSMENT: STRENGTHS AND LIMITATIONS OF EPIDEMIOLOGIC STUDIES

EPIDEMIOLOGY AND DOSE RECONSTRUCTION

STUDY DESIGN

Study Types

Statistical Power

Outcomes

Population Identification and Follow-Up

Bias and Confounding

Statistical Analysis

Uncertainty and Misclassification

SUMMARY AND RECOMMENDATIONS.

8 Priority Criteria for Dose Assessment Studies

BASIC CRITERIA

DECISION CRITERIA

FINAL RANKING

9 Conclusions

10 Literature Cited

Appendix A Representative Dose Reconstruction Studies

NEVADA TEST SITE

CHERNOBYL

THREE MILE ISLAND

FERNALD

HANFORD

TECHA RIVER

GOIANIA

NOTES

Appendix B Workshop Agenda

DOSE RECONSTRUCTION FOR EPIDEMIOLOGIC USES AGENDA

Appendix C Workshop Participants

KEYNOTE SPEAKERS

SOURCE TERM ESTIMATION

ENVIRONMENTAL PATHWAYS

BIOMARKERS

RADIATION DOSE ASSESSMENT

EPIDEMIOLOGY

Appendix D Glossary

Index.

Notes:

Bibliographic Level Mode of Issuance: Monograph

Includes bibliographical references (p. 93-101) and index.

Other Format:

Print version: Staff, National Research Council. Radiation-Dose Reconstruction for Epidemiologic Uses.

ISBN:

9786610211043

9780309176835

0309176832

9781280211041

1280211040

9780309587136

0309587131

9780585002392

0585002398

OCLC:

42328527