Putting biotechnology to work : bioprocess engineering / Committee on Bioprocess Engineering, Board on Biology, Commission on Life Sciences, National Research Council.

Format:

Book

Author/Creator:

National Research Council (U.S.). Committee on Bioprocess Engineering.

Language:

English

Subjects (All):

Biochemical engineering.

Biotechnology.

Physical Description:

1 online resource (132 p.)

Edition:

1st ed.

Place of Publication:

Washington, D.C. : National Academy of Sciences, 1992.

Language Note:

English

Summary:

The ability of the United States to sustain a dominant global position in biotechnology lies in maintaining its primacy in basic life-science research and developing a strong resource base for bioprocess engineering and bioproduct manufacturing. This book examines the status of bioprocessing and biotechnology in the United States; current bioprocess technology, products, and opportunities; and challenges of the future and what must be done to meet those challenges. It gives recommendations for action to provide suitable incentives to establish a national program in bioprocess-engineering research, development, education, and technology transfer.

Contents:

PUTTING BIOTECHNOLOGY TO WORK BIOPROCESS ENGINEERING

Copyright

Preface

Contents

Executive Summary

BIOPROCESS ENGINEERING AND GLOBAL COMPETITIVENESS

OPPORTUNITIES

NEEDS

RECOMMENDATIONS

A PLAN FOR ACTION

Human-Resources Development

Assessing Developments Abroad

Cross-disciplinary Research

Promoting Awareness of Importance of Manufacturing Technology

Competitive-Grants Program

Role of National Laboratories and Research Centers

Bioprocessing for Cleanup of Environmental Hazards

1 Introduction

1.1 BIOTECHNOLOGY: THE CHALLENGE OF THE TWENTY-FIRST CENTURY

1.2 WHAT IS BIOPROCESS ENGINEERING?

1.3 THE COMMITTEE'S APPROACH

1.4 ECONOMIC IMPACT OF BIOTECHNOLOGY

1.5 ROLE OF BIOPROCESS ENGINEERING

1.6 BARRIERS TO EXPLOITATION OF BIOTECHNOLOGY

2 The Challenge

2.1 TRANSLATING SCIENCE INTO PRODUCTS

2.2 BIOPHARMACEUTICALS

2.2.1 New Technology Required for Biopharmaceuticals

2.2.2 Bioprocess Engineering Requires Many Disciplines

2.2.3 Opportunities

2.3 THE ENVIRONMENT

2.4 CONVERSION OF RENEWABLE AND NONRENEWABLE RESOURCES

2.4.1 Renewable Resources

2.4.2 Nonrenewable Resources

2.4.3 Coupled Synthesis Gas

2.4.4 Enhanced Oil Recovery

2.4.5 Opportunities

2.5 SPACE

2.6 BIOTECHNOLOGY-RESEARCH INITIATIVE GIVEN BY FEDERAL COORDINATING COUNCIL FOR SCIENCE, ENGINEERING, AND TECHNOLOGY (FCCSET)

2.7 SUMMARY

2.8 REFERENCES

3 Benchmarking: Status of U.S. Bioprocessing and Biotechnology

3.1 BIOPROCESS ENGINEERING IN JAPAN

3.1.1 Education and Training

3.1.2 University-Industry Cooperation

3.1.3 Scientific and Technological Information-Gathering

3.1.4 Summary of Comparison With United States

3.2 BIOPROCESS ENGINEERING IN GERMANY AND EUROPE

3.2.1 Education

3.2.2 University Research in Germany

3.3 BIOPROCESS ENGINEERING IN UNITED STATES.

3.3.1 Education and Training

3.3.2 Government Initiative and Support

3.4 SUMMARY

3.5 REFERENCES

4 Current Bioprocess Technology, Products, and Opportunities

4.1 BIOPHARMACEUTICALS

4.1.1 Proteins from Recombinant Microorganisms

4.1.2 Inclusion Bodies

4.1.3 Mammalian Host Systems

4.1.4 Other Hosts for Heterologous Gene Expression

4.1.5 Isolation and Purification

4.1.6 Protein Engineering

4.1.7 Glycobiology

4.1.8 Metabolic Engineering

4.1.9 Polymerase Chain Reaction

4.1.10 Monoclonal Antibodies and Antibody Engineering

4.1.11 Transgenic Animals

4.1.12 Product Formulation

4.1.13 Research Needs

4.2 SPECIALTY BIOPRODUCTS AND INDUSTRIAL CHEMICALS

4.2.1 Enzyme Technology and Specialty Bioproducts

4.2.2 Biopesticides

4.2.3 Microalgae and New Chemicals

4.2.4 Plant-Cell Tissue Culture

4.2.5 Research Needs and Opportunities

4.3 ENVIRONMENTAL APPLICATIONS

4.3.1 Bioremediation

4.3.2 Point-of-Source Biocontrol

4.3.3 Agriculture

4.3.4 Mining

4.3.5 Microbial-Enhanced Oil Recovery

4.3.6 Research Needs and Opportunities

4.4 REFERENCES

5 Needs: What Must Be Done to Meet the Challenges

5.1 EDUCATION AND TRAINING

5.1.1 Science-Engineering Interface

5.1.2 Multidisciplinary Team Research

5.1.3 Industry-University Interface

5.1.4 Bioprocess Equipment Engineers

5.1.5 Diversification and Specialized Training

5.1.6 Curriculum Development

5.2 RESEARCH

5.3 TECHNOLOGY TRANSFER

5.3.1 University-Industry Relationships

5.3.2 International Exploitation

5.4 REFERENCES

6 The Future

6.1 OPPORTUNITIES

6.1.1 Biopharmaceuticals and Biopesticides from Insect Cell-Baculovirus System

6.1.2 Gene-Based Pharmaceuticals and Gene Therapy

6.1.3 New Catalysts

6.1.4 Cells, Organs, and Biomaterials

6.1.5 Transgenic Animals

6.1.6 Transgenic Plants.

6.1.7 Nontraditional Organisms

6.1.8 Energy and Renewable Resources

6.1.9 Agricultural Chemicals and Food

6.1.10 Plant-Cell Culture

6.1.11 Plants and Seeds

6.1.12 The Environment

6.1.13 Space

6.2 DEFENSE AND NATIONAL SECURITY

6.2.1 Cleanup

6.2.2 Chemical and Biological Warfare

6.2.3 Stabilization of Developing Countries

6.3 NEEDS

6.3.1 Education and Training

6.3.2 Technology

6.3.3 Manufacturing

6.4 RECOMMENDATIONS

6.5 REFERENCES

Bibliography

Appendix A Biographical Sketches of Committee Members

Appendix B Invited Speakers at Committee Meetings

Index.

Notes:

Bibliographic Level Mode of Issuance: Monograph

Includes bibliographical references (p. 102-103) and index.

ISBN:

9786610196241

9781280196249

1280196246

9780309584876

0309584876

9780585143538

0585143536

OCLC:

44955880