Multiple chemical sensitivities : addendum to Biologic markers in immunotoxicology / Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council.

Format:

Book

Contributor:

National Research Council (U.S.). Board on Environmental Studies and Toxicology.

National Research Council (U.S.). Commission on Life Sciences.

Language:

English

Subjects (All):

Multiple chemical sensitivity.

Chemicals--Health aspects.

Chemicals.

Physical Description:

1 online resource (200 pages)

Edition:

1st ed.

Place of Publication:

Washington, D.C. : National Academy Press, 1992.

Language Note:

English

Summary:

Use of the term "multiple chemical sensitivity" (MCS) as a diagnostic label has generated increasing controversy during the past few decades as a phenomenon related to exposure to chemical agents sustained both in indoor and outdoor environments. This volume, prepared in conjunction with Biologic Markers in Immunotoxicology , contains the authored papers of a workshop held to develop an agenda to study the phenomenon of multiple chemical sensitivity. Authored by clinicians, immunologists, toxicologists, epidemiologists, psychiatrists, psychologists, and others involved in research or clinical activities relevant to the problem, the papers contain case evaluations and criteria for diagnosis, mechanisms potentially underlying MCS, and epidemiologic approaches to investigation.

Contents:

""Multiple Chemical Sensitivities""; ""Copyright""; ""Contents""; ""Introduction""; ""REFERENCES""; ""OVERVIEW""; ""Research Protocol for Clinical Evaluation""; ""WORKING GROUP I""; ""CASE CRITERIA""; ""CANDIDATE POPULATIONS""; ""EVALUATION""; ""Exposures and Mechanisms""; ""WORKING GROUP II""; ""HUMAN STUDIES""; ""OTHER EXPERIMENTAL APPROACHES""; ""ADDITIONAL NEEDS""; ""Epidemiology""; ""WORKING GROUP III""; ""Key Concepts: Chemical Sensitization""; ""INTRODUCTION""; ""MECHANISMS OF SENSITIZATION""; ""Classic Sensitization""; ""Inflammation""; ""Other Mechanisms of Sensitization""

""Different Pathways"" ""Irritant Mechanisms""; ""FORMALDEHYDE""; ""Potential Mechanisms of Formaldehyde Induced Respiratory Sensitivity""; ""Evidence of Asthma in Humans""; ""Skin Sensitization""; ""Current Levels of Knowledge""; ""REFERENCES""; ""Multiple Chemical Sensitivity-What is It?""; ""REFERENCES""; ""Case Definitions for Multiple Chemical Sensitivity""; ""TERMINOLOGY""; ""REFERENCES""; ""Allergy and Multiple Chemical Sensitivities Distinguished""; ""SUMMARY OF ADAPTATION HYPOTHESES""; ""REFERENCES""; ""Design of Animal Models to Probe the Mechanisms of Multiple Chemical Sensitivity""

""INTRODUCTION""""ANIMAL MODELS OF ENVIRONMENTAL LUNG DISEASES""; ""Monitoring of Responses""; ""EVALUATION OF ANIMAL MODELS""; ""Respiratory Hypersensitivity""; ""Guinea Pig Model of Airway Hyperreactivity""; ""ANIMAL MODEL FOR ORGANIC DUST TOXIC SYNDROME""; ""AN ANIMAL MODEL OF MCS""; ""SUMMARY""; ""ACKNOWLEDGEMENT""; ""REFERENCES""; ""Antigen Specific and Antigen Non-Specific Immunization""; ""REFERENCES""; ""Neuropsychiatric & Biopsychosocial Mechanisms in Multiple Chemical Sensitivity: An Olfactory-Limbic System Model""; ""INTRODUCTION""

""CONTROLLED STUDIES ON MULTIPLE CHEMICAL SENSITIVITY PATIENTS""""OLFACTORY-LIMBIC SYSTEM MODEL AND AFFECTIVE SPECTRUM DISORDERS""; ""Affective Spectrum Disorders""; ""Olfactory Bulbectomy Model of Depression""; ""Anxiety Disorders and Environmental Chemicals""; ""Kindling and Long-Term Potentiation in the Limbic System: Possible Role in the Mechanisms of MCS""; ""Brain Electrical Activity and Chemical Exposures""; ""PSYCHOSOCIAL MODULATORS OF BIOLOGICAL EVENTS""; ""Possible Mediators in MCS""; ""Classical Conditioning Hypothesis""; ""METHODOLOGICAL ISSUES""; ""CONCLUSIONS""; ""REFERENCES""

""Neurobehavioral and Psychosocial Aspects of Multiple Chemical Sensitivity"" ""CHARACTERISTICS OF MCS PATIENTS""; ""PSYCHOSOCIAL AND PSYCHIATRIC EVALUATION""; ""RESULTS AND CONCLUSION""; ""CONCLUSION""; ""REFERENCES""; ""Acknowledgments""; ""Diagnostic Markers of Multiple Chemical Sensitivity""; ""INTRODUCTION""; ""MATERIALS AND METHODS""; ""RESULTS""; ""DISCUSSION""; ""CONCLUSIONS""; ""REFERENCES""; ""Possible Mechanisms for Multiple Chemical Sensitivity: The Limbic System and Others""; ""MECHANISMS INVOLVING THE LIMBIC SYSTEM""; ""BIOCHEMICAL MECHANISMS""; ""VASCULAR MECHANISMS"" ""REFERENCES""

Notes:

Description based upon print version of record.

Includes bibliographical references.

ISBN:

9786610203246

9781280203244

1280203242

9780309597968

030959796X

9780585149318

0585149313

OCLC:

923265125