Adverse reproductive outcomes in families of atomic veterans : the feasibility of epidemiologic studies / Committee to Study the Feasibility of, and Need for, Epidemiologic Studies of Adverse Reproductive Outcomes in the Families of Atomic Veterans, Medical Follow-up Agency, Institute of Medicine.

Format:

Book

Contributor:

Institute of Medicine (U.S.). Committee to Study the Feasibility of, and Need for, Epidemiologic Studies of Adverse Reproductive Outcomes in the Families of Atomic Veterans.

Language:

English

Subjects (All):

Radiation--Physiological effect.

Radiation.

Veterans--Diseases.

Veterans.

Radiation victims.

Teratogenesis.

Abnormalities, Human.

Physical Description:

x, 97 p.

Edition:

1st ed.

Place of Publication:

Washington, D.C. : National Academy Press, 1995.

Language Note:

English

Summary:

Over the past several decades, public concern over exposure to ionizing radiation has increased. This concern has manifested itself in different ways depending on the perception of risk to different individuals and different groups and the circumstances of their exposure. One such group are those U.S. servicemen (the "Atomic Veterans" who participated in the atmospheric testing of nuclear weapons at the Nevada Test Site or in the Pacific Proving Grounds, who served with occupation forces in or near Hiroshima and Nagasaki, or who were prisoners of war in or near those cities at the time of, or shortly after, the atomic bombings. This book addresses the feasibility of conducting an epidemiologic study to determine if there is an increased risk of adverse reproductive outcomes in the spouses, children, and grandchildren of the Atomic Veterans.

Contents:

Adverse Reproductive Outcomes in Families of Atomic Veterans: The Feasibility of Epidemiologic Studies

Copyright

Preface

Contents

Executive Summary

CONCLUSIONS

ORGANIZATION AND FRAMEWORK OF THE REPORT

ADVERSE REPRODUCTIVE OUTCOMES

ESTIMATION OF GENETIC RISK

FEASIBILITY OF AN EPIDEMIOLOGIC STUDY

Question 1. Definition of the Study Sample

Question 2. Sample Size

Question 3. Dose

Question 4. Identification of Adverse Reproductive Outcomes

ALTERNATIVE APPROACHES

1 Introduction

AIMS OF THIS REPORT

2 Basic Epidemiologic Issues

3 Feasibility and Design of an Epidemiologic Study

STUDY COHORT

MEASUREMENT OF EXPOSURE

DEFINING THE DISEASE AND ASCERTAINING THE CASES

4 Basic Principles of Radiation Biology

BIOLOGICAL EFFECTS

SOURCES OF RADIATION EXPOSURE

POTENTIALLY SENSITIVE SUBGROUPS

5 Genetic Principles and Issues

6 Current Knowledge and Estimation of Genetic Risk

BASIC ESTIMATION EQUATION

DATA FROM WHICH RISK ESTIMATES HAVE BEEN MADE

Mice

Humans

Estimating the Spontaneous Burden

Estimating the Effect of Ionizing Radiation

ESTIMATING THE DOUBLING DOSE

7 Adverse Reproductive Outcomes

GENERAL REMARKS

MALE-MEDIATED REPRODUCTIVE AND DEVELOPMENTAL OUTCOMES

INFERTILITY

Radionuclide Irradiation

SPONTANEOUS ABORTIONS

PRETERM DELIVERY

STILLBIRTHS AND NEONATAL DEATHS (PERINATAL DEATHS)

BIRTH DEFECTS

Human Chromosome Abnormalities

Developmental Abnormalities

MATERNAL ILLNESSES

ALTERED SEX RATIO

MORTALITY AMONG THE CHILDREN OF EXPOSED PARENTS

CANCER AND LEUKEMIA IN PARTICULAR

IMMUNE DEFICIENCY

NEUROLOGIC DEFICIT, INCLUDING MENTAL RETARDATION

8 Feasibility of the Study of Adverse Reproductive Outcomes in the Families of Veterans Exposed Ionizing Radiation.

DEFINITION OF A SUITABLE SAMPLE OR COHORT

SIZE OF THE SAMPLE OR COHORT REQUIRED

Question 1

Question 2

DOSIMETRY OF ATOMIC VETERANS

IDENTIFICATION OF ADVERSE REPRODUCTIVE OUTCOMES

9 Alternative Approaches

10 Conclusions

Glossary

References.

Notes:

"Support for this project was provided by the Department of Veterans Affairs (contract no. V101-(93)P-1469)"--T.p. verso.

Includes bibliographical references (p. 91-97).

ISBN:

9786610192670

9780309176118

0309176115

9781280192678

1280192674

9780309588485

0309588480

9780585143354

0585143358

OCLC:

923261963