Rodents / Committee on Rodents, Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council.

Format:

Book

Contributor:

Institute of Laboratory Animal Resources (U.S.). Committee on Rodents.

Series:

Laboratory animal management.

Laboratory animal management

Language:

English

Subjects (All):

Rodents as laboratory animals.

Physical Description:

1 online resource (179 pages) : illustrations

Edition:

1st ed.

Place of Publication:

Washington, D.C. : National Academy Press, 1996.

Language Note:

English

Summary:

During the 15 years since the Institute of Laboratory Animal Resources issued its last report on the general management of rodents, advances in biomedical technology and increased public awareness of laboratory animal issues have created a new research environment. This book brings researchers up to date on both of these aspects of laboratory investigation and provides a comprehensive resource manual for management of laboratory rodents. It reviews relevant laws and ethical considerations, and it examines the role and responsibilities of mandatory institutional animal care and use committees. The expert panel addresses animal selection, sources of laboratory rodents, nomenclature and record keeping, management of genetically and nongenetically defined colonies, and management of animals with special needs. Investigators will find detailed guidance on housing, environment, sanitation, diet and caloric restriction, and facilities design.

Contents:

Rodents

Copyright

Preface

Contents

1 Laboratory Animals and Public Perspective

REGULATORY ISSUES

ETHICAL CONSIDERATIONS

REFERENCES

2 Responsibilities of Animal Care and Use Committees

PROGRAM OVERSIGHT

PROTOCOL REVIEW

PERSONNEL QUALIFICATIONS AND TRAINING

OCCUPATIONAL HEALTH AND SAFETY

USE OF HAZARDOUS AGENTS

3 Criteria for Selecting Experimental Animals

SPECIES AND STOCKS

Choosing a Species for Study

Rodent Stocks

Genetically Defined Stocks

Nongenetically Defined Stocks

STANDARDIZED NOMENCLATURE FOR RODENTS

Inbred Strains

Substrains

Laboratory Codes

F1 Hybrids

Coisogenic, Congenic, and Segregating Inbred Strains

Recombinant Inbred (RI) Strains

Genes

Loci That Are Members of a Series

Alleles

Transgenes

Outbred Stocks

QUALITY

Microbiologic Quality

Genetic Quality

SELECTED ASPECTS OF EXPERIMENTAL DESIGN

4 Genetic Management of Breeding Colonies

GENETICALLY DEFINED STOCKS

Pedigrees

Traceability

Selection of Parental Pairs

Genetic Uniformity

Foundation or Nucleus Colonies, Expansion Colonies, and Production Colonies

NONGENETICALLY DEFINED STOCKS

CRYOPRESERVATION

RECORD-KEEPING

5 Husbandry

HOUSING

Caging

Housing Systems

Space Recommendations

ENVIRONMENT

Microenvironment

Temperature

Humidity

Ventilation

Ventilation Rate

Air Quality

Relative Air Pressures

Cage Ventilation

Illumination

Spectral Distribution

Photoperiod

Intensity

Noise

FOOD

Types of Diets

Criteria for Selecting Optimal Rations

Quality Assurance

Caloric Restriction

WATER

BEDDING

SANITATION

Cleaning

Waste Containment and Disposal

Pest Control

IDENTIFICATION AND RECORDS

RODENTS OTHER THAN RATS AND MICE

Guinea Pigs.

Hamsters

Gerbils

Chinchillas

6 Veterinary Care

PREVENTIVE MEDICINE

Procurement

Sources

Transportation

Quarantine and Stabilization

Separation by Species, Source, and Health Status

SURVEILLANCE, DIAGNOSIS, TREATMENT, AND CONTROL OF DISEASE

Daily Observations of Animals

Control of Infectious Diseases

Sample Size for Monitoring

Treatment and Control

Necropsies

EMERGENCY, WEEKEND, AND HOLIDAY CARE

MINIMIZATION OF PAIN AND DISTRESS

Recognition of Pain and Distress

Alleviation of Pain

Alleviation of Stress and Distress

SURVIVAL SURGERY AND POSTSURGICAL CARE

Anesthetics and Tranquilizers

Preparation for Survival Surgery

Sterilization of Instruments

Monitoring During Surgery

Postoperative Care

EUTHANASIA

7 Facilities

LOCATION AND DESIGN

Centralization Versus Decentralization

Functional Areas

Space Requirements

Relative Relationships of Space

Corridors, Vestibules, and Anterooms

Interstitial Space

CONSTRUCTION AND ARCHITECTURAL FINISHES

MONITORING

SPECIAL REQUIREMENTS

SECURITY

8 Rodents that Require Special Consideration

IMMUNODEFICIENT RODENTS

Husbandry

Plastic Cages with Filter Tops

Individually Ventilated Plastic Cages with Filter Tops

Isolators

HEPA-Filtered Airflow Systems

Environmental Considerations

Food and Bedding

Water

Health Monitoring

WILD RODENTS

Hazards

Care and Breeding

Peromyscus

Woodchucks

AGING COHORTS

General Considerations

Laboratory Mice

Rats (Rattus norvegicus)

Record-Keeping

Transportation and Stabilization

Veterinary Care and Surveillance

Other Rodent Species Used for Gerontological Research

Other Species of Mus

Peromyscus spp.

Guinea Pigs

Hamsters

Gerbils.

RODENT MODELS OF INSULIN-DEPENDENT DIABETES MELLITUS

Diabetes-Prone and Diabetes-Resistant Rats

Breeding Techniques and Genetic Records

Husbandry and Care

Use of Spleen Cells to Reduce Frequency of Diabetes and Improve Breeding Efficiency

Shipping Pathogen-Free Rats

NOD Mice

TRANSGENIC MICE

Colony Management

Embryo Donors

Embryo Recipients

Offspring

Breeding Transgenic Mice

Identification, Records, and Genetic Monitoring

Embryo Cryopreservation

Data Management

Shipment and Receipt of Transgenic Rodents

Human Health Hazards

Administrative Issues

Appendix Sources of Information on Importing Rodents

Index.

Notes:

Bibliographic Level Mode of Issuance: Monograph

Includes bibliographical references and index.

ISBN:

9786610196050

9780309176927

0309176921

9781280196058

128019605X

9780309585774

0309585775

9780585019949

0585019940

OCLC:

42854156