Nanocomposites for musculoskeletal tissue regeneration / edited by Huinan Liu.

Format:

Book

Contributor:

Liu, Huinan, editor.

Class of 1932 Fund.

Series:

Woodhead Publishing series in biomaterials ; no. 109.

Woodhead Publishing series in biomaterials

Language:

English

Subjects (All):

Nanocomposites (Materials).

Biomedical materials.

Tissue engineering.

Physical Description:

xix, 385 pages : illustrations (some color) ; 24 cm.

Place of Publication:

Duxford, UK : Woodhead Publishing is an imprint of Elsevier, 2016.

Summary:

As no one material can effectively mimic the structure of Musculoskeletal tissues, scientists have looked to advanced biomaterials as substitutes. Bone and other Musculoskeletal tissues naturally have a nanocomposite structure; therefore nanocomposites are ideally suited as a material for replacing and regenerating these natural tissues. In addition biological properties such as biointegration and the ability to tailor and dope the materials make them highly desirable for Musculoskeletal tissue regeneration. Nanocomposites for Musculoskeletal Tissue Regeneration provides readers with a through review of biocomposites and their role in musculoskeletal tissue regeneration. Part one reviews designing nanocomposites for musculoskeletal tissue regeneration. Part two looks at the properties of these important materials and polymer nanocomposites for musculoskeletal tissue regeneration. The final set of chapters cover ceramic and glass nanocomposites for bone tissue regeneration. Book jacket.

Contents:

Part 1 Designing nanocomposites for musculoskeletal tissue regeneration 1

1 Design and fabrication of nanocomposites for musculoskeletal tissue Regeneration / N. Narayanan Narayanan, N., L. Kuang Kuang, L., M. Del Ponte Ponte, M. Del, C. Chain Chain, C., M. Deng Deng, M. 3

1.1 Introduction 3

1.2 Design considerations of nanocomposites for musculoskeletal tissue engineering 5

1.3 Fabrication of nanocomposites for musculoskeletal tissue engineering 12

1.4 Conclusions 17

Acknowledgments 19

References 19

2 Carbon and inorganic nanomaterial-reinforced polymeric nanocomposites for bone tissue engineering / G. Lalwani Lalwani, G., M. D'Agati D'Agati, M., B. Farshid Farshid, B., B. Sitharaman Sitharaman, B. 31

2.1 Introduction 31

2.2 Nanomaterial-reinforced polymeric nanocomposites 34

2.3 Design criteria and nanomaterial properties for maximum mechanical reinforcement 43

2.4 In vitro and in vivo cyto- and biocompatibility of nanomaterial-reinforced polymeric nanocomposites 46

2.5 Summary and future perspective 59

References 60

3 Effects of surface modification on polymeric biocomposites for orthopedic applications / A.J. Harmata Harmata, A.J., S.A. Guelcher Guelcher, S.A. 67

3.1 Introduction 67

3.2 Orthopedic applications 68

3.3 Surface modifications of solid fillers 70

3.4 Polymeric biocomposites 73

3.5 Effects of surface modification on filler properties 79

3.6 Effects of surface-modified fillers on the properties of resultant polymeric biocomposites 84

3.7 Future trends 86

Sources of further information and advice 88

References 88

Part 2 Polymer nanocomposites for musculoskeletal tissue regeneration 93

4 Toxicity and biocompatibility properties of nanocomposites for musculoskeletal tissue regeneration / W. Liu Liu, W., T.J. Webster Webster, T.J. 95

4.1 Introduction 95

4.2 Musculoskeletal tissue and natural nanocomposite structures 97

4.3 Biocompatibility and toxicity of nanocomposites 97

4.4 Biocompatibility and toxicity for musculoskeletal tissue 104

4.5 Conclusions and future perspectives 115

References 116

5 Advanced polymer composites and structures for bone and cartilage tissue engineering / P. Sol Sol, P., A. Martins Martins, A., R.L. Reis Reis, R.L., N.M. Neves Neves, N.M. 123

5.1 Introduction 123

5.2 The natural extracellular matrix 123

5.3 The requirements of structures for tissue engineering 126

5.4 Polymer composite structures for bone and cartilage tissue engineering 127

5.5 Functionalization of composite structures for bone and cartilage tissue engineering 131

5.6 Conclusions and future trends 137

Acknowledgments 137

References 137

6 Bioactive polymer nanocomposites for spinal cord tissue engineering / P. Kumar Kumar, P., Y.E. Choonara Choonara, Y.E., G. Modi Modi, G., V. Pillay Pillay, V. 143

6.1 Introduction 143

6.2 Bioactive-loaded nanoenclatherated polymer composites 144

6.3 Biomaterial carbon nanotube composites 152

6.4 Future trends 155

List of abbreviations 156

References 157

7 Chitosan-nanohydroxyapatite nanocomposite for bone-tissue regeneration / J. Venkatesan Venkatesan, J., R. Jayakumar Jayakumar, R., S. Anil Anil, S., S.-K. Kim Kim, S.-K. 161

7.1 Introduction 161

7.2 Nanohydroxyapatite 161

7.3 Chitosan 162

7.4 Chitosan-nHA composite scaffolds 162

7.5 Future directions 168

7.6 Conclusion 168

Acknowledgments 169

References 169

8 Polymer nanocomposites for drug delivery applications in bone tissue regeneration / V. Mouriño Mouriño, V. 175

8.1 Introduction and challenges 175

8.2 Bioactive molecule-releasing scaffolds for bone tissue engineering 178

8.3 Conclusions and future trends 182

References 183

Further reading 186

9 Fabrication of cellulosic composite scaffolds for cartilage tissue engineering / A.G. Nandgaonkar Nandgaonkar, A.G., W.E. Krause Krause, W.E., L.A. Lucia Lucia, L.A. 187

9.1 Introduction 187

9.2 Structure, composition, and anatomy of articular cartilage 188

9.3 Motivation for cartilage tissue engineering 191

9.4 Cartilage tissue engineering 192

9.5 Cellulose-based materials for cartilage tissue engineering 193

9.6 Bacterial cellulose properties and suitability as a medical implant for cartilage tissue engineering 200

9.7 Conclusions and future outlook 206

References 207

10 Electrospun scaffolds for cartilage regeneration / C.B. Horner Horner, C.B., K. Low Low, K., J. Nam Nam, J. 213

10.1 Introduction 213

10.2 Synthesis of electrospun scaffolds 216

10.3 Electrospun scaffolds for cartilage regeneration 225

10.4 Current limitations of electrospun scaffolds in cartilage tissue engineering 233

References 234

11 Nanocomposites for bone repair and osteointegration with soft tissues / W. Jiang Jiang, W., H. Liu Liu, H. 241

11.1 Introduction 241

11.2 Bone composition and structures 241

11.3 Healing mechanism of bone injury 243

11.4 Bone-tissue repair and regeneration 244

11.5 Materials for bone repair and regeneration 244

11.6 Conclusion 253

References 254

12 Biomimetic nanocomposite hydrogels for cartilage regeneration / N.J. Castro Castro, N.J., L.G. Zhang Zhang, L.G. 259

12.1 Introduction 259

12.2 Hydrogels for cartilage regeneration 261

12.3 Nanocomposite-cartilage scaffold fabrication 265

12.4 In vitro testing considerations: cell sources 270

12.5 Conclusion 271

Acknowledgments 272

References 272

Part 3 Ceramic and glass nanocomposites for musculoskeletal tissue regeneration 283

13 Biomimetic phosphate nanocomposites for bone-tissue regeneration / J. Buschmann Buschmann, J. 285

13.1 Introduction 285

13.2 Biomimesis of bone tissue 285

13.3 Fabrication of biomimetic phosphate nanocomposites 296

List of abbreviations 299

References 300

14 Hydroxyapatite nanocomposites for tendon repair / J. Xie Xie, J., J. Jiang Jiang, J., M.J. Teusink Teusink, M.J., F.D. Shuler Shuler, F.D. 307

14.1 Introduction 307

14.2 Basics of tendon-to-bone insertion 308

14.3 Mechanism of hydroxyapatite minerals for tendon-to-bone insertion repair 314

14.4 Hydroxyapatite nanocomposites for tendon-to-bone insertion repair 314

14.5 Conclusions and perspectives 323

Acknowledgments 324

References 324

15 Ceramic-polymer nanocomposites for bone-tissue regeneration / P. Palmero Palmero, P. 331

15.1 Introduction 331

15.2 Bone as a natural ceramic-polymer nanocomposite 332

15.3 Requirements for scaffolds in bone-tissue engineering 334

15.4 Materials for bone-tissue regeneration: ceramics and polymers 336

15.5 Nanocomposites for bone-tissue regeneration: properties and processing 342

15.6 Ceramic-polymer nanocomposites for tissue regeneration: state of the art and possible applications 347

15.7 Concluding remarks 359

List of abbreviations 360

References 360.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Class of 1932 Fund.

ISBN:

1782424520

9781782424529

OCLC:

928780289

Publisher Number:

99971679698