Diverse roles for T-bet in the immune response to Toxoplasma gondii / Gretchen Harms Pritchard.

Format:

Book

Manuscript

Thesis/Dissertation

Author/Creator:

Harms Pritchard, Gretchen, author.

Contributor:

Hunter, Chris (Christopher A.), degree supervisor.

Laufer, Terri M., degree committee member.

Oliver, Paula, degree committee member.

Sin, Sŏn-hwa, degree committee member.

Wells, Andrew, degree committee member.

Wherry, E. John, degree committee member.

University of Pennsylvania. Department of Immunology, degree granting institution.

Language:

English

Subjects (All):

Penn dissertations--Immunology.

Immunology--Penn dissertations.

Local Subjects:

Penn dissertations--Immunology.

Immunology--Penn dissertations.

Physical Description:

xi, 148 leaves : illustrations ; 29 cm

Production:

[Philadelphia, Pennsylvania] : University of Pennsylvania, 2016.

Summary:

The T-box transcription factor T-bet is most prominently known for its role in production of the cytokine interferon-γ (IFNγ) by effector T cells after infection with Th1-inducing pathogens. Here, we demonstrate additional roles for T-bet during effector T cell responses including an essential function in T cell trafficking to secondary sites of infection during toxoplasmosis. Mice that are deficient in T-bet are unable to survive infection with the intracellular parasite Toxoplasma gondii, and this mortality is caused by uncontrolled parasite replication at secondary sites of infection and is associated with a paucity of T cells at these sites. Additionally, we provide evidence that T-bet is also involved in early events of T cell priming and expansion. Together, the data presented in this thesis provide a better understanding of the diverse roles that T-bet plays in the generation and function of T cell responses during the immune response to T. gondii.

Notes:

Ph. D. University of Pennsylvania 2016.

Department: Immunology.

Supervisor: Christopher A. Hunter.

Includes bibliographical references.

OCLC:

982016978