Dendrites : Development and Disease / edited by Kazuo Emoto, Rachel Wong, Eric Huang, Casper Hoogenraad.

Format:

Book

Contributor:

Emoto, Kazuo, editor.

Wong, Rachel O., editor.

Huang, Eric, editor.

Hoogenraad, Casper, editor.

SpringerLink (Online service)

Language:

English

Subjects (All):

Medicine.

Neurosciences.

Neurology.

Animal models in research.

Physical Description:

1 online resource

Contained In:

Springer eBooks

Place of Publication:

Tokyo : Springer Japan : Imprint: Springer, 2016.

System Details:

text file PDF

Summary:

Studies in human patients and animal models of disease suggest a strong correlation between defects in dendrite development and common neurological disorders such as autism. Much of this book is thus dedicated toward highlighting recent advances in our understanding of the cellular and molecular mechanisms that regulate the development and maintenance of dendrites, a crucial component of neurons. The book begins by presenting the current state of knowledge on the building blocks or cell biology of dendrites. Mechanisms that sculpt the stereotypic architecture of dendritic arbors and shape their connectivity are also discussed, along with recent work describing how dendritic organization and connectivity are perturbed in disease. A unique aspect of the book is its exploration of diverse neuronal cell types across vertebrates and invertebrates, allowing a comparison of mechanisms across distinct circuits and species. The book comprises six parts, which cover the major advances in the field: Part 1, Introduction; Part 2, Basic Biology of Dendrites; Part 3, Patterning Dendritic Architecture of Neurons and Their Populations; Part 4, Cellular and Molecular Control of Dendrite Development and Maintenance; Part 5, Synapse Formation onto Dendrites; and Part 6, Dendrites in Disease. The book offers an excellent point of entry for students interested in neuroscience, as well as for clinicians.

Contents:

Part 1 Introduction

1 Introduction

Part 2 Basic biology of dendrites

2 Cytoskeletal organization - actin

3 Cytoskeletal organization - microtubules

4 Membrane trafficking mechanisms: -endo/exocytosis

5 Synapse to nucleus signaling

6 Ultrastructural methods

7 Bioimaging of dendritic signaling

Part 3 Patterning dendritic architecture of neurons and their populations

8 Self-avoidance

9 Dendritic tiling

10 Mosaics and lamination

11 Modifying dendritic structure after function

Part 4 Cellular and molecular control of dendrite development and maintenance

12 Molecular control of dendrite development

13 Sensory-dependent regulation of dendritic morphology

14 Dendrite maintenance

Part 5 Synapse formation onto dendrites

15 Molecular assembly of excitatory synapses

16 Localizing receptors and channels across the dendritic arbor

17 Synaptic adhesion molecules

18 Balancing excitatory and inhibitory inputs

19 Assembly and reassembly of synapses

Part 6 Dendrites in disease

20 Dendrite development in autism and autism-related disorders

21 Dendrite degeneration in Frontotemporal dementia

22 Dendrite degeneration and Glaucoma.

Other Format:

Printed edition:

ISBN:

9784431560500

Access Restriction:

Restricted for use by site license.