Biochemistry of Oxidative Stress : Physiopathology and Clinical Aspects / edited by Ricardo Jorge Gelpi, Alberto Boveris, Juan José Poderoso.

Format:

Book

Contributor:

Gelpi, Ricardo Jorge, editor.

Boveris, Alberto, editor.

Poderoso, Juan José, editor.

SpringerLink (Online service)

Series:

Advances in biochemistry in health and disease ; 16.

Advances in Biochemistry in Health and Disease ; 16

Language:

English

Subjects (All):

Medicine.

Cancer--Research.

Cancer.

Cell physiology.

Oxidative stress.

Physical Description:

1 online resource.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2016.

System Details:

text file PDF

Summary:

The strongest point of this book titled "Biochemistry of Oxidative Stress: Physiopathology and Clinical Aspects", is that the academic and scientific background of the authors/editors guarantee the authorship of a book comprising all aspects of oxidative stress, ranging from very molecular aspects, to clinical application, including the antioxidant therapy. Of particular importance is the fact that the aforementioned aspects are described in the book in a general section and in three different and important pathologies, such as cardiovascular diseases, neurodegenerative diseases, and cancer. The importance of these pathologies lays in the fact that, taken separately or together, they represent by far the leading cause of death in the world. Finally, all the chapters have been written by highly recognized authorities in the field of their investigations. At least to our knowledge, this is the first book with this characteristics in the field of oxidative stress.

Contents:

Introduction

Section 1 GENERAL ASPECTS: 1 The concept of oxidative stress after 30 years

2 Evolution of atmospheric oxygen and oxygen metabolism

3 Mitochondria as origin of cellular oxidative stress

4 Biochemistry and physiology of mtNOS

5 Biochemistry of nitrogen reactive species

6 Biochemistry of nitro fatty acids

7 Mammalian adaptation to life at high altitude

8 Metabolic syndrome and oxidative stress in rat pancreas

9 Progesterone prevents mitochondrial dysfunction and oxidative stress in the spinal cord of wobbler mice

10 Mitochondrial transfer by intercellular nanotubes

Section 2 CARDIOVASCULAR: 11 Role of Oxidative Stress in Subcellular Defects in Ischemic Heart Disease

12 Regulation of protein nitrosylation by Trx1

13 Inhibition of adenylyl cyclase type 5 increases longevity and healthful aging through oxidative stress protection

14 Antioxidant supplementation in elderly cardiovascular patients

15 Rupture of redox homeostasis in a model of pulmonary artery

16 Mitochondrial reactive oxygen species triggered by the cardiac renin-angiotensin-aldosterone system

17 Mitochondrial complex I inactivation and increased autooxidation after ischemia-reperfusion in the stunned heart

18 Oxidized LDL and atherogenesis

19 Reactive oxygen species and cyclooxygenase products in the regulation of blood flow in small vessels

20 Thioredoxin-1 attenuates postischemic ventricular and mitochondrial dysfunctions

21 Nitro-arachidonic acid reduces the damaged area in rat myocardial infarction

22 Inhaled particulate matter and myocardial dysfunction

Section 3 NEURODEGENERATION AND NEURONAL FUNCTION: 23 Effect of lipoic acid in the triple transgenic mouse model of Alzhaimer's disease

24 Neurovascular coupling mediated by NO in the hippocampus

25 Protection from neurodegeneration: signaling and mitocondrial regulation

26 Oxidative stress and neurodegeneration

27 Oxidative stress, metabolic syndrome and Alzheimer ́s disease

28 Systemic oxidative stress in patients with neurodegenerative diseases

Section 4 CANCER: 29 Oxygen metabolism and oxidative stress in cancer cells

30 Mitochondrial biogenesis is required for survival and propagation of cancer cells

31 Tumor immunology & immunotherapy in patients

32 Oncogene-induced Nrf2 repression as adaptive response of cancer cells to acquire a pro-oxidant state favoring cell survival and in vivo tumor growth

33 Mitochondrial dynamics regulate oxidative metabolism in Leydig tumor cells

Index.

Other Format:

Printed edition:

ISBN:

9783319458656

Access Restriction:

Restricted for use by site license.