Systems Pharmacology and Pharmacodynamics / edited by Donald E. Mager, Holly H.C. Kimko.

Format:

Book

Contributor:

Mager, Donald E., editor.

Kimko, Holly H.C., editor.

SpringerLink (Online service)

Series:

AAPS advances in the pharmaceutical sciences series 2210-7371 ; 23.

AAPS Advances in the Pharmaceutical Sciences Series, 2210-7371 ; 23

Language:

English

Subjects (All):

Medicine.

Pharmaceutical technology.

Clinical biochemistry.

Biomathematics.

Physical Description:

1 online resource.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2016.

System Details:

text file PDF

Summary:

While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.

Contents:

Role of Systems Modeling in Regulatory Drug Approval

Quantitative Systems Pharmacology: Applications and Adoption in Drug Development

Systems Pharmacology: An Overview

Discrete dynamic modeling: a network approach for systems pharmacology

Kinetic Models of Biochemical Signaling Networks

Mechanistic Models of Physiological Control Systems

Foundations of Pharmacodynamic Systems Analysis

Direct, Indirect, and Signal Transduction Response Modeling

Irreversible Pharmacodynamics

Feedback Control Indirect Response Models

Nonlinear Mixed Effects Modeling in Systems Pharmacology

Detecting Pharmacokinetic and Pharmacodynamic Covariates From High-Dimensional Data

Multi-Scale Modeling of Drug Action in the Nervous System

Mechanistic Modeling of Inflammation

Systems Pharmacology of Tyrosine Kinase Inhibitor-Associated Toxicities

Translational Modeling of Antibacterial Agents

Viral Dynamic Modeling of Hepatitis C Virus Infection: Past Successes and Future Challenges

Using Systems Pharmacology to Advance Oncology Drug Development

Systems Pharmacology Modeling in Type 2 Diabetes Mellitus.

Other Format:

Printed edition:

ISBN:

9783319445342

Access Restriction:

Restricted for use by site license.