Selenium : Its Molecular Biology and Role in Human Health / edited by Dolph L. Hatfield, Ulrich Schweizer, Petra A. Tsuji, Vadim N. Gladyshev.

Format:

Book

Contributor:

Hatfield, Dolph L., editor.

Schweizer, Ulrich, editor.

Tsuji, Petra A. (Petra Akiko), editor.

Gladyshev, Vadim N., editor.

SpringerLink (Online service)

Language:

English

Subjects (All):

Medicine.

Immunology.

Nutrition.

Physical Description:

1 online resource

Edition:

Fourth edition 2016.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2016.

System Details:

text file PDF

Summary:

In the current edition, Selenium: Its Molecular Biology and Role in Human Health expands extensively on the previous editions providing readers with the most significant advances in the rapidly developing selenium field. Evidence from epidemiology and veterinary science supports the essential role of selenium in (human) health, but its split personality in both preventing and supporting cancer and also in promoting insulin resistance has become more clearly defined. The pivotal role of glutathione peroxidase 4 in a new process of programmed cell death, ferroptosis, brings new impetus to the field. Recently defined mutations in selenoprotein and biosynthesis factor genes have been identified in patients, and the resulting disorders further emphasize the significance of selenoproteins in human health. The mechanism of selenoprotein biosynthesis, the functions of selenoproteins, and the roles of dietary selenium have been further elucidated, and new regulatory mechanisms involving selenoproteins discovered. The book, therefore, covers the breadth of current selenium research. With up-to-date chapters written by leaders in their fields, it serves as an invaluable resource for novices as well as specialists.

Contents:

Part I. The machinery of selenoprotein biosynthesis

1 Selenocysteine tRNA[Ser]Sec: From nonsense suppressor tRNA to the quintessential constituent in selenoprotein biosynthesis

2 Eukaryotic mechanisms of selenocysteine translation and its reconstitution in vitro

3 Probing selenoprotein translation by ribosome profiling

4 Pathways in de novo biosynthesis of selenocysteine and cysteine in eukaryotes

5 Prokaryotic selenoprotein biosynthesis and function

6 The role of selenium in human evolution

7 The chemistry of selenocysteine in proteins

8 Evolution of selenophosphate synthetase

9 Structure and mechanism of selenocysteine synthases

10 Mechanism, structure, and biological role of selenocysteine lyase

Part II. Selenoproteins, their occurrence and function

11 Eukaryotic selenoproteomes

12 Prokaryotic selenoproteins and selenoproteomes

13 Functional genomics of selenoproteins and Se-responsive pathways

14 Selenium regulation of the selenoprotein and non-selenoprotein transcriptomes in a variety of species

15 77Se NMR spectroscopy of selenoproteins

16 Thioredoxin reductase 1 as an anticancer drug target

17 Basics and news on glutathione peroxidases

18 Glutathione Peroxidase 4

19 The 15 kDa Selenoprotein: Insights into its regulation and function

20 Selenoprotein K and protein palmitoylation in regulating immune cell functions

21 Selenoprotein M: Structure, expression and functional relevance

22 Selenoprotein P and selenium distribution in mammals

23 Selenoprotein T: From discovery to functional studies using conditional knockout mice

24 Biochemistry and function of methionine sulfoxide reductase

Part III. Dietary selenium and its impact on human health

25 Selenium: Dietary sources, human nutritional requirements and intake across populations

26 Human clinical trials involving selenium

27 Status of dietary selenium in cancer prevention

28 Selenium in HIV/AIDS

29 Genetic variations in the genes for selenoproteins implicate the encoded proteins in cancer etiology

30 Is adequate selenium important for healthy human pregnancy?

31 The epidemiology of selenium and human health

32 Sex-specific differences in biological effects and metabolism of selenium

33 Selenium and endocrine tissues

34 Selenium antagonism with mercury and arsenic: from chemistry to population health and demography

35 Biological selenium species and selenium speciation in biological samples

36 Selenoproteins in nervous system development, function and degeneration

37 Interplay of selenoproteins and different antioxidant systems in various cancers

38 Glutathione peroxidase 2, a selenoprotein exhibiting a dual personality in preventing and promoting cancer

39 Selenoproteins in cardiovascular redox pathology

40 What do we know about selenium contributions to muscle physiology?

41 Tissue-specific regulation of thyroid status by selenodeiodinases

42 The role of selenoproteins in resolution of inflammation

43 Glutathione peroxidase 4 and ferroptosis

44 Mutations in humans that adversely affect the selenoprotein synthesis pathway

45 Alteration of selenoprotein expression during stress and in aging

Part V. Biological models for elucidating the role of selenium and selenoproteins in biology and medicine

46 Selenocysteine tRNA[Ser]Sec mouse models for elucidating roles of selenoproteins in health and development

47 Mouse models that target individual selenoproteins

48 The naked mole rat and selenium

49 Glutathione peroxidase 1: Models for diabetes and obesity

50 Selenium in livestock and other domestic animals.

Other Format:

Printed edition:

ISBN:

9783319412832

Access Restriction:

Restricted for use by site license.