Protein moonlighting in biology and medicine / Brian Henderson (Division of Infection and Immunity, University College London, London, UK), Mario A. Fares (Institute of Integrative Systems Biology (CSIC-UV), Valencia, Spain, Trinity College Dublin, Dublin, Ireland), Andrew C.R. Martin (Division of Biosciences, University College London, London, UK).

Format:

Book

Author/Creator:

Henderson, Brian (Professor), author.

Fares, Mario A., author.

Martin, Andrew C. R., author.

Language:

English

Subjects (All):

Proteins--Structure.

Proteins.

Proteins--Evolution.

Physical Description:

xii, 313 pages, 4 unnumbered pages of plates : illustrations (some color) ; 25 cm

Place of Publication:

Hoboken, New Jersey : Wiley Blackwell, [2017]

Summary:

The past 25 years have seen the emergence of a wealth of data suggesting that novel biological functions of known proteins play important roles in biology and medicine. This ability of proteins to exhibit more than one unique biological activity is known as "protein moonlighting." Moonlighting proteins can exhibit novel biological functions, thus extending the function of the proteome, and are also implicated in the pathology of a growing number of idiopathic and infectious diseases. Protein Moonlighting in Biology and Medicine written by a cell biologist, protein evolutionary biologist and protein bioinformatician, brings together the latest information on the structure, evolution and biological function of the growing numbers of moonlighting proteins that have been identified, and their roles in human health and disease. This information is revealing the enormous importance protein moonlighting plays in the maintenance of human health and in the induction of disease pathology. This book will be of interest to a general readership in the biological and biomedical research community. Book jacket.

Contents:

An introduction to the protein molecule

How proteins evolve

A brief history of protein moonlighting

The structural basis to protein moonlighting

Protein moonlighting and new thoughts about protein evolution

Biological consequences of protein moonlighting

Protein moonlighting and human health and idiopathic human disease

Protein moonlighting and infectious disease

Protein moonlighting : the future.

Notes:

Includes bibliographical references and index.

Other Format:

Online version: Henderson, Brian (Professor), author. Protein moonlighting in biology and medicine

ISBN:

9781118952085

1118952081

OCLC:

970401162