Viral pathogenesis : from basics to systems biology / edited by Michael G. Katze, Department of Microbiology, University of Washington, Seattle, WA, USA, [and 3 others].

Format:

Book

Contributor:

Katze, Michael G., editor.

Language:

English

Subjects (All):

Virus diseases--Pathogenesis.

Virus diseases.

Viruses--pathogenicity.

Virus Diseases--etiology.

Virus Diseases--immunology.

Medical Subjects:

Viruses--pathogenicity.

Virus Diseases--etiology.

Virus Diseases--immunology.

Genre:

Electronic books.

Physical Description:

1 online resource

Edition:

Third edition.

Place of Publication:

London, UK : Academic Press, [2016]

System Details:

text file

Summary:

Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology.

Contents:

Part I: History and essentials of viral pathogenesis

1. The human toll of viral diseases / Neal Nathanson

2. Historical roots / William C. Summers

3. Basic concepts / Robert W. Doms

4. Innate immunity / Christine A. Biron

5. Adaptive immunity / E. John Wherry and David Masopust

6. Aberrant immunity / E. John Wherry and David Masopust

7. Patterns of infection / Neal Nathanson and Francisco González-Scarano

8. Viral oncogenesis / Nicholas A. Wallace and Denise A. Galloway

9. HIV and AIDS / Guido Silvestri and Emily K. Cartwright

10. Animal models / Victoria K. Baxter and Diane E. Griffin

Part II: Systems-level approaches to viral pathogenesis

11. Systems virology / Marcus J. Korth and G. Lynn Law

12. The virus-host interactome / Monika Schneider, Jeffery R. Johnson, Nevan J. Krogan and Sumit K. Chanda

13. Host genetics / Martin T. Ferris, Mark T. Heise and Ralph S. Baric

14. Metabolomics and lipidomics / Priscilla L. Yang

15. Mathematical modeling / Alan S. Perelson

Part III: Emergence and control of viral infections

16. Emerging viral diseases / James W. Le Duc and Neal Nathanson

17. Viral evolution / Adi Stem and Raul Andino

18. Viral epidemiology / Kaitlin Rainwater-Lovett, Isabel Rodriguez-Barraquer and William J. Moss

19. Viral vaccines / Juliet Morrison and Stanley Plotkin

20. Antiviral therapy / Douglas D. Richman and Neal Nathanson

Part IV: Prizes and predictions for viral pathogenesis

21. Breakthrough / Neal Nathanson

22. What lies ahead?

Notes:

Includes bibliographical references and index.

Vendor-supplied metadata.

ISBN:

9780128011744

0128011742

OCLC:

933611305

Access Restriction:

Restricted for use by site license.