Introduction to tissue engineering : applications and challenges / Ravi Birla.

Format:

Book

Author/Creator:

Birla, Ravi, author.

Series:

IEEE Press series in biomedical engineering

IEEE Press Series on Biomedical Engineering

Language:

English

Subjects (All):

Tissue engineering.

Genre:

Electronic books.

Physical Description:

1 online resource (358 pages) : color illustrations.

Place of Publication:

Hoboken, New Jersey : Wiley, 2014.

System Details:

text file

Summary:

A Comprehensive reference and teaching aid on tissue engineering-covering everything from the basics of regenerative medicine to more advanced and forward thinking topics such as the artificial liver, bladder, and trachea, Regenerative medicine/tissue engineering is the process of replacing or regenerating human cells, tissues, or organs to restore or establish normal function. It is an incredibly progressive field of medicine that may, in the near future, help with the shortage of life-saving organs available through donation for transplantation. Introduction to Tissue Engineering: Applications and Challenges makes tissue engineering more accessible to undergraduate and graduate students alike. It provides a systematic and logical eight-step process for tissue fabrication. Specific chapters have been dedicated to provide in-depth principles for many of the supporting and enabling technologies during the tissue fabrication process and include biomaterial development and synthesis, bioreactor design, and tissue vascularization. the tissue fabrication process is further illustrated with specific examples for liver, bladder, and trachea. Section-coverage includes an overall introduction of tissue engineering; enabling and supporting technologies; clinical applications; and case studies and future challenges. Introduction to Tissue Engineering: Presents medical applications of stem cells in tissue engineering, Deals with the effects of chemical stimulation (growth factors and hormones), Covers current disease pathologies and treatment options, (pacemakers, prosthesis), Explains bioengineering, design and fabrication, and critical challenges during tissue fabrication, Offers PowerPoint® slides for instructors, Features case studies and a section on future directions and challenges As Pioneering individuals look ahead to the possibility of generating entire organ systems, students may turn to this text for a comprehensive understanding and preparation for the future of regenerative medicine. Book jacket.

Contents:

1 Introduction to Tissue Engineering 1

1.1 Introduction to Tissue Engineering 2

1.2 Chronic Shortage of Donor Organs 3

1.3 The Tissue Engineering Paradigm 4

1.4 Definition of Tissue Engineering 5

1.5 Process of Bioengineering 3D Artificial Tissue 9

1.6 Design Principles for Tissue Engineering 12

1.7 Building Blocks of Tissue Engineering 14

1.8 Scientfic and Technological Challenges 15

1.9 Functional Assessment of Artificial Tissue 16

1.10 Seminal Papers in Tissue Engineering 18

1.11 Applications of 3D Artificial Tissue 20

1.12 Two-Dimensional Versus Three-Dimensional Culture 22

1.13 Integration of Core Technologies 22

1.14 Growth of Tissue Engineering 24

1.15 Disciplines in Tissue Engineering 26

1.16 Tissue Engineering and Related Fields 28

Summary 33

Practice Questions 34

References 35

2 Cells for Tissue Engineering

2.1 Cells and Tissue Engineering 41

2.2 Cell Structure and Function 43

2.3 The Dynamic Extracellular Matrix 47

2.4 Cell Signaling 48

2.5 Cellular Junctions 50

2.6 Mammalian Tissue and Artificial Tissue 52

2.7 Cell Sourcing 52

2.8 The Cell Transplantation Process 55

2.9 Cells for Cell Transplantation 58

2.10 Mode of Action of Cells During Cell Transplantation 59

2.11 Cell Transplantation and Tissue Engineering 60

2.12 The Cell Culture Process 61

2.13 Applications of Monolayer 2D Cells Culture 64

2.14 Cell Culture Versus Tissue Engineering 65

2.15 Introduction to Stem Cell Engineering 66

2.16 Human Embryonic Stem Cells 70

2.17 Induced Pluripotent Stem Cells 71

2.18 Adult Stem Cells 72

Summary 72

Practice Questions 73

References 74

3 Biomaterials for Tissue Engineering 84

3.1 Definition of Biomaterials 85

3.2 Scheme for Biomaterial Development 88

3.3 Historical Perspective on Biomaterials 90

3.4 Tensile Properties 92

3.5 Modulation of Tensile Properties 95

3.6 Material Degradation 97

3.7 Biocompatibility 100

3.8 Biomimetic Biomaterial 104

3.9 Classification of Biomaterials 106

3.10 Biomaterial Platforms 108

3.11 Smart Materials 113

3.12 The Dynamic Extracellular Matrix 114

3.13 Idealized Biomaterial 116

Summary 118

Practice Questions 119

References 121

4 Tissue Fabrication Technology 131

4.1 Introduction to Tissue Fabrication Techologies 131

4.2 Self-Organization Technology 133

4.3 Cell Sheet Engineering 135

4.4 Scaffold-Based Tissue Fabrication 137

4.5 Cell and Organ Printing 140

4.6 Solid Freeform Fabrication 142

4.7 Soft Lithography and Microfiuidics 143

4.8 Cell Patterning 145

4.9 Idealized System to Support Tissue Fabrication 148

Summary 149

Practice Questions 150

References 151

5 Vascularization of Artificial Tissue

5.1 Introduction 157

5.2 Seminal Publications in Angiogenesis Research 159

5.3 Vascularization Defined 160

5.4 Molecular Mechanism of Vasculogenesis 161

5.5 Molecular Mechanism of Angiogenesis 163

5.6 Molecular Machanism of Arteriogenesis 164

5.7 Thearapeutic Angiogenesis 166

5.8 Tissue Engineering and Vascularization 167

5.9 Conceptual Framework for Vascularization During Artificial Tissue Formation 169

5.10 In Vivo Models of Vascularization 172

5.11 Idealized Vascularization Strategy for Tissue Engineering 174

5.12 Flow Chart and Decision Making 176

5.13 Biologically Replicated Vascularization Strategies 179

5.14 Biologically Mediated Vascularization Strategies 179

5.15 Biologically Inspired Vascularization Strategies 184

Summary 186

Practice Questions 187

References 188

6 Bioreactors for Tissue Engineering 193

6.1 Introduction to Bioreactors 194

6.2 Bioreactors Defined 195

6.3 Classification of Bioreactors 197

6.4 Desigh Considerations 200

6.5 Idealized Bioreactor System 202

6.6 Bioreactors and Tissue Engineering 205

6.7 Bioreactors for Mammalian Cell Culture 207

6.8 Bioreactors for Scaffold Fabrication 209

6.9 Bioreactors for Scaffold Cellularization 212

6.10 Perfusion Systems 215

6.11 Bioreactors for Stretch 219

6.12 Electrical Stimulation 221

Summary 226

Practice Questions 227

References 230

7 Tracheal Tissue Engineering 237

7.1 Stucture and Function of the Trachea 238

7.2 Congenital Tracheal Stenosis 240

7.3 Genetic Regulation of Tracheal Development 241

7.4 Post Intubation and Post Tracheostomy Tracheal Stenosis 243

7.5 Tretment Modalities for Tracheal Stenosis 245

7.6 Design Considerations for Tracheal Tissue Engineering 247

7.7 Process of Bioengineering Artificial Tracheas 247

7.8 Tissue Engineering Models for Artificial Tracheas 250

7.9 Trachel Tissue Engineering

Ann Example of a Clinical Study 253

7.10 Tracheal Tissue Engineering

A Second Example of a Clinical

Study 255

Summary 258

Practice Questions 258

References 260

8 Bladder Tissue Engineering 265

8.1 Bladder Structure and Function 266

8.2 Neurogenic Bladder Dysfunction 267

8.3 Surgical Bladder Augmentation 269

8.4 Development of the Urinary Bladder 270

8.5 Design Considerations for Bladder Tissue Engineering 270

8.6 Process of Bioengineering Artificial Bladders 271

8.7 Cell Sheet Engineering for Bladder Tissue Engineering 273

8.8 Small Intestinal Submucosa (SIS) for Bladder Tissue Engineering 275

8.9 Plga as a Biomaterial for Bladder Tissue Engineering 278

8.10 Acellular Grafts for Bladder Tissue Engineering 280

8.11 Organ Models for Bladder Tissue Engineering 283

8.12 Clinical Study for Bladder Tissue Engineering 284

Summary 285

Practice Questions 286

References 288

9 Liver Tissue Engineering 295

9.1 Structure and Function of the Liver 296

9.2 Acute Liver Failure 297

9.3 Liver Transplantation 299

9.4 Liver Regeneration 301

9.5 Liver Development 302

9.6 Design Considerations for Liver Tissue Engineering 303

9.7 Process of Bioengineering Artificial Liver Tissue 303

9.8 Stem Cells for Liver Tissue Engineering 305

9.9 Surface Patterning Technology for Liver Tissue Engineering 307

9.10 Biomaterial Platforms for Liver Tissue Engineering 309

9.11 Fabrication of 3D Artificial Liver Tissue 309

9.12 Vascularization for Liver Tissue Engineering 311

9.13 Bioreactors for Liver Tissue Engineering 312

9.14 Spheroid Culture for Liver Tissue Engineering 313

Summary 314

Practice Questions 315

References 317.

Notes:

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

Local Notes:

Electronic reproduction. Palo Alto, Calif. : ebrary, 2015. Available via World Wide Web. Access may be limited to ebrary affiliated libraries.

Other Format:

Print version: Birla, Ravi. Introduction to tissue engineering : applications and challenges.

ISBN:

9781118828014

OCLC:

883376356

Access Restriction:

Restricted for use by site license.