Alzheimer's disease : life course perspectives on risk reduction / Amy R. Borenstein, Ph.D., M.P.H. and James A. Mortimer, Ph.D., University of South Florida, Department of Epidemiology and Biostatistics, Department of Neurology, Tampa, FL, USA.

Format:

Book

Author/Creator:

Borenstein, Amy R., author.

Mortimer, James A., author.

Language:

English

Subjects (All):

Alzheimer's disease--Epidemiology.

Alzheimer's disease.

Alzheimer's disease--Prevention.

Epidemiology.

Genre:

Electronic books.

Physical Description:

1 online resource

polychrome

Place of Publication:

Amsterdam : Academic Press is an imprint of Elsevier, [2016]

System Details:

text file

Summary:

Alzheimer's Disease: Lifecourse Perspectives on Risk Reduction summarizes the growing body of knowledge on the distribution and causes of Alzheimer's disease (AD) in human populations, providing the reader with knowledge on how we define the disease and what its risk and protective factors are in the context of a life-course approach. At the conclusion of the book, the reader will understand why Alzheimer's disease likely begins at conception, then progresses through early-life and adult risk factors that ultimately impact the balance between pathologic insults in the brain and the ability of the brain to modify disease symptoms. In contrast to edited volumes that may have little cohesion, this book focuses on an integrated life-course approach to the epidemiology of dementia, in particular, Alzheimer's disease.

Contents:

Front Cover; Alzheimer's Disease; Copyright Page; Dedication; Contents; Preface; Acknowledgments; Prologue: A Primer on Epidemiologic Concepts and Methods; I. Defining a Case; 1 The "First" Case; 2 Clinical Appearance, Progression, and Classification; What is Dementia?; Course and Progression of Dementia; Clinical Research Criteria for Dementia; Clinical Research Criteria for other Dementias; Clinical Research Criteria for AD (NINCDS-ADRDA); Clinical Research Criteria for VaD (NINDS-AIREN); Vascular Cognitive Impairment; ICD9/10: Another Method of Classifying Dementia;

Mild Cognitive ImpairmentClassification of MCI and Dementia Using Neuropsychological Testing; Episodic Memory; Language and Semantic Knowledge; Executive Function and Attention; Visuospatial Function; Need for Standardization; 3 Epidemiologic Definition of a Case; 4 Neuropathology of Alzheimer's Disease; Clinicopathologic Studies; Criteria for Neuropathologic AD; Continuous Measures of Neuropathologic Severity; Population Attributable Fraction of Pathologies in the Causation of Dementia; Is Neuropathologic AD an Inevitable Outcome of Aging?; Do Women Have More Alzheimer's Pathology Than Men?;

Clinicopathologic Studies Provide Information About the Pathogenesis of DementiaMRI-Neuropathologic Associations; Is Atrophy the Final Common Pathway Linking Brain Pathology with Dementia?; Comments; 5 The Threshold Model of Dementia; The Threshold Model of Dementia; What Is Reserve and How Can We Measure it?; II. Descriptive Epidemiology; 6 The Prevalence of Alzheimer's Disease; Case Definition and Detection; Prevalence of AD in the United States; Worldwide Prevalence Rates of AD and Dementia; Prevalence of MCI; Methodological Issues in Prevalence Studies; Prevalence Rates by Age;

Prevalence Rates by Sex Prevalence of AD and Other Subtypes; Prevalence and Race Or Ethnicity; Prevalence and Place; 7 The Incidence of Alzheimer's Disease; Incidence Rates by Age and Sex; Cumulative Lifetime Risk; Incidence of MCI; If They Live Long Enough, Will Everyone Get Dementia?; Incidence by Sex; Incidence and Race; Incidence and Place; Incidence and Time Trends; 8 Survival and Mortality in Alzheimer's Disease; AD in the Top 10 Leading Causes of Death; Competing Causes of Death; III. Analytic Epidemiology; 9 Introduction to the Analytic Epidemiology of Alzheimer's Disease;

History and Methodological Aspects of Analytic Studies of AD: Case-Control StudiesProspective Cohort Studies; A Third Set of Risk Factors for AD; 10 Family History, Genetics, and Down Syndrome; Early Family Studies; Case-Control Studies and Family History of Dementia; Cohort Studies and Family History of Dementia; How Genetic is Alzheimer's Disease?; Familial AD and the Discovery of Genetic Mutations; Other Susceptiblity Genetic Variants; Down Syndrome; 11 Early-Life Factors; The Life Course Approach; The Prenatal Environment; The Intrauterine Environment; Birth Order and Sibship Size

Notes:

Online resource ; title from PDF title page (EBSCO, viewed February 22, 2016).

Includes bibliographical references and index.

Other Format:

Print version: Borenstein, Amy Alzheimer's Disease : Life Course Perspectives on Risk Reduction

ISBN:

9780124171541

0124171540

OCLC:

939960491

Access Restriction:

Restricted for use by site license.