Characterisation and design of tissue scaffolds / edited by Paul Tomlins.

Format:

Book

Contributor:

Tomlins, Paul, editor.

Sabin W. Colton, Jr., Memorial Fund.

Series:

Woodhead Publishing series in biomaterials ; no. 106.

Woodhead Publishing series in biomaterials

Language:

English

Subjects (All):

Tissue scaffolds.

Tissue engineering--Materials.

Tissue engineering.

Biomedical materials.

Materials.

Genre:

Electronic books.

Physical Description:

1 online resource : illustrations.

polychrome

Place of Publication:

Cambridge, UK : Woodhead Publishing, an imprint of Elsevier, [2016]

System Details:

text file

Summary:

Characterisation and Design of Tissue Scaffolds offers scientists a useful guide on the characterization of tissue scaffolds, detailing what needs to be measured and why, how such measurements can be made, and addressing industrially important issues. Part one provides readers with information on the fundamental considerations in the characterization of tissue scaffolds, while other sections detail how to prepare tissue scaffolds, discuss techniques in characterization, and present practical considerations for manufacturers.

Contents:

1 Material types for tissue scaffolds / P. Tomlins Tomlins, P. 1

Introduction 1

Polymers 2

Synthetic polymers 7

Synthetic proteins 9

Ceramics 9

De-cellularized matrices 11

Characterization of materials 11

Sterilization 13

Future trends 13

Sources of further information 14

References 14

2 Designing and modeling pore size distribution in tissue scaffolds / Y. Elsayed Elsayed, Y., C. Lekakou Lekakou, C. 23

Background 23

Modeling of pore architecture and its effect on the process of tissue engineering 25

Selection of fabrication technique in terms of pore size distribution-with emphasis on polymer-based scaffolds 30

Electrospinning of tissue engineered vascular grafts-the effect of pore morphology on tire mechanical and biological functionality of the scaffolds: a case study 34

Conclusion 40

References 41

3 Computer modeling of the degradation behavior of polyester-based tissue engineering scaffolds / H. Samami Samami, H. 45

Introduction 45

Tissue engineering scaffolds 46

Factors controlling the degradation rate of scaffolds 47

A mathematical model for the degradation of bioresorbable polyesters 50

Computer modeling of scaffold degradation using finite element methods 56

Conclusion 71

References 72

4 Decellularization of mammalian tissues: preparing extracellular matrix bioscaffolds / T.J. Keane Keane, T.J., L.T. Saldin Saldin, L.T., S.F. Badylak Badylak, S.F. 75

Introduction 75

Rationale and relevance for clinical use of decellularized tissues 77

Establishing a criteria for decellularization efficacy 78

Decellularization agents 79

Decellularization techniques 87

Terminal sterilization of decellularized tissues 93

Conclusion 95

References 95

5 Preparation of polymer-based porous scaffolds for tissue engineering / G. Chen Chen, G., N. Kawazoe Kawazoe, N. 105

Introduction 105

Preparation methods of porous polymer scaffolds 106

Preparation of porous scaffolds with ice-particulates 108

Scaffolds with open surface pores and micropatterned structures 112

Hybrid scaffolds 118

Scaffolds with stratified structures 122

Conclusions 123

References 124

6 Characterizing the degradation behavior of bioceramic scaffolds / O-M. Goudouri Goudouri, O-M., P. Balasubramanian Balasubramanian, P., A.R. Boccaccini Boccaccini, A.R. 127

Introduction 127

Calcium phosphate-based scaffolds 129

Apatite/wollastonite scaffolds 134

Other polycrystalline ceramic scaffolds 136

Bioactive glass-based scaffolds 137

Characterisation needs/challenges 140

Conclusions 141

References 142

7 Characterization of tissue scaffolds drug release profiles / M. Prabaharan Prabaharan, M. 149

Introduction 149

Properties of scaffolds in drug delivery 150

Methods of drug loading 154

Determination of drug loading efficiency 157

Mechanism of drug delivery 158

Types of drug release 160

Determination of the in vitro drug release kinetics 161

Determination of in vitro drug release profiles 162

Summary 164

References 165

8 Stereological assessment of engineered tissues and their scaffolds / P. Dockery Dockery, P., M. Biggs Biggs, M. 169

Introduction 169

The stereological approach 173

Stereological estimators 178

Conclusion 187

Accessing the literature 187

New directions 188

References 189

9 Image analysis and quantification of tissue scaffolds / Y. Yang Yang, Y., I. Wimpenny Wimpenny, I. 201

Laboratory-based imaging modalities for porous scaffolds in tissue engineering 201

Important parameters for monitoring scaffolds in culture 208

μ-CT 217

Conclusion 220

References 221

10 Sterilization of tissue scaffolds / A.S. Baume Baume, A.S., P.C. Boughton Boughton, P.C., N.V. Coleman Coleman, N.V., A.J. Ruys Ruys, A.J. 225

Sterilization 225

Effects of sterilization on scaffolds 230

Sterilization and scaffold design 238

References 241

11 Practical relevance and interpretation of characterization data / P. Tomlins Tomlins, P. 245

Introduction 245

A quantitative assessment of biocompatibility 246

Structural characterization of tissue scaffolds 247

Surface texture 255

Chemical composition 257

Degradation of tissue scaffolds 258

Mechanical properties 259

Assessing the performance of a scaffold: Darcy permeability 260

Sterilization issues 261

Using standard test methods 261

Discussion 264

References 265.

Notes:

Includes bibliographical references and index.

Online resource; title from PDF title page (EBSCO, viewed November 5, 2015).

Local Notes:

Acquired for the Penn Libraries with assistance from the Sabin W. Colton, Jr., Memorial Fund.

ISBN:

9781782420958

1782420959

OCLC:

927438019

Access Restriction:

Restricted for use by site license.