Life histories of genetic disease : patterns and prevention in postwar medical genetics / Andrew J. Hogan.

Format:

Book

Author/Creator:

Hogan, Andrew J., author.

Language:

English

Subjects (All):

Medical genetics.

Medical genetics--Moral and ethical aspects.

Genetic disorders iagnosis.

Genetic disorders.

Genetic Diseases, Inborn--prevention & control.

Genetics, Medical--history.

History, 20th Century.

History, 21st Century.

Medical Subjects:

Genetic Diseases, Inborn--prevention & control.

Genetics, Medical--history.

History, 20th Century.

History, 21st Century.

Physical Description:

xv, 259 pages ; 24 cm

Place of Publication:

Baltimore : Johns Hopkins University Press, [2016]

Summary:

Medical geneticists began mapping the chromosomal infrastructure piece by piece in the 1970s by focusing on what was known about individual genetic disorders. Five decades later, their infrastructure had become an edifice for prevention, allowing today's expecting parents to choose to test prenatally for hundreds of disease-specific mutations using powerful genetic testing platforms. In Life Histories of Genetic Disease, Andrew J. Hogan explores how various diseases were "made genetic" after 1960, with the long-term aim of treating and curing them using gene therapy. In the process, he explains, these disorders were located in the human genome and became targets for prenatal prevention, while the ongoing promise of gene therapy remained on the distant horizon. In narrating the history of research that contributed to diagnostic genetic medicine, Hogan describes the expanding scope of prenatal diagnosis and prevention. He draws on case studies of Prader-Willi, fragile X, DiGeorge, and velo-cardio-facial syndromes to illustrate that almost all testing in medical genetics is inseparable from the larger-and increasingly "big data"-oriented-aims of biomedical research.

Contents:

Introduction : pursuing a better birth

Genetics detectives

Chromosomal cartography

The genome's morbid anatomy

Seeing with molecules

Institutionalized disorders

Getting the whole picture

Epilogue : the genomic gaze.

Notes:

Includes bibliographical references and index.

Other Format:

Electronic version: Hogan, Andrew J. Life histories of genetic disease.

ISBN:

9781421420745

1421420740

9781421420752

1421420759

OCLC:

934019893