Conquering RAS : from biology to cancer therapy / edited by Asfar S. Azmi.

Format:

Book

Author/Creator:

Azmi, Asfar S., author.

Contributor:

ScienceDirect (Online service).

Dr. D. Sergeant Pepper Memorial Fund.

Language:

English

Subjects (All):

Ras oncogenes.

Genes, ras.

Medical Subjects:

Genes, ras.

Physical Description:

1 online resource (xviii, 275 pages)

polychrome

Place of Publication:

London, UK : Academic Press is an imprint of Elsevier, [2017]

System Details:

text file

Summary:

A review of RAS biology from basic science through translational application, Key Features, Brings together wide ranging topics in RAS basic and translational biology for the scientific and clinical community, Showcases the recent advances in RAS research in one comprehensive volume, Includes detailed color illustrations, and important website links to facilitate clear understanding of RAS in cancer research, Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of new technological developments. Each chapter is written in a manner emphasizing simplicity and readability for both new investigators and established researchers in this fast-moving field. While RAS biology has been intensively studied for more than three decades, we have yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene. Conquering RAS: From Biology to Cancer Therapy covers topics ranging from basic RAS biology to translational biology and drug discovery applications. These topics are essential for basic researchers working on the lab bench who seek deeper understanding of the modern concepts in RAS research. Similarly, the oncologist at the patient's bedside will find the book useful as they routinely face the daunting task of treating patients that predominantly have a disease driven by oncogenic KRAS. Book jacket.

Contents:

Front Cover; Conquering RAS: From Biology to Cancer Therapy; Conquering RAS: From Biology to Cancer Therapy; Copyright; Dedication; Contents; List of Contributors; Acknowledgments; Introduction; 01

RAS Cancer Biology ; 1

Ras and RASSF Effector Proteins ; INTRODUCTION; The RASSF Family of Proteins; RAS AND RASSF1; RAS AND RASSF5 (NORE1); RAS AND RASSF2; RAS AND RASSF3; RAS AND RASSF4 (AD037); RAS AND RASSF6; EFFECTS OF RASSF PROTEINS ON MITOGENIC RAS EFFECTORS; THERAPEUTIC RAMIFICATIONS; CONCLUSION; GLOSSARY; LIST OF/ACRONYMS AND/ABBREVIATIONS; REFERENCES

2

Ras and the Hippo Pathway in Cancer INTRODUCTION; THE HIPPO TUMOR SUPPRESSOR PATHWAY; MST AND LATS AS THE CENTRAL MAMMALIAN KINASES UNDER THE INFLUENCE OF HIPPO/SIGNALING; YAP SIGNALING AND ITS REGULATION BY HIPPO; CONCLUSIONS AND FUTURE DIRECTIONS; REFERENCES; 3

The Many Roles of Ral GTPases in Ras-Driven Cancer ; INTRODUCTION; RAL REGULATION; RalGEFs; RalGAPs; Localization; RAL EFFECTORS; RalBP1; Exocyst; Additional Effectors; RAL IN MODEL SYSTEMS; RAL IN TUMORIGENESIS; INHIBITION OF RAL; CONCLUSIONS AND FUTURE DIRECTIONS; REFERENCES

4

The Biology, Prognostic Relevance, and Targeted Treatment of Ras Pathway-Positive Childhood Acute Lymphoblastic Leukemia INTRODUCTION; CHILDHOOD ALL; RAS PATHWAY ACTIVATION; ARE RAS PATHWAY MUTATIONS AN INITIATING OR SECONDARY EVENT?; DISEASE EVOLUTION; PROGNOSTIC SIGNIFICANCE; TARGETED THERAPIES; CONCLUSIONS; LIST OF ACRONYMS AND ABBREVIATIONS; REFERENCES; 5

Oncogenic KRAS and the Inflammatory Micro-Environment in Pancreatic Cancer ; ONCOGENIC KRAS DRIVES PANCREATIC CANCER DEVELOPMENT; THE IMPORTANCE/OF INFLAMMATION/IN PDAC/DEVELOPMENT

INTER-RELATION BETWEEN ONCOGENIC KRAS AND INFLAMMATION/IN PANCREATIC/CANCEROncogenic Kras Induces Inflammatory Pathways in Pancreatic Cancer; Inflammation Reciprocally Promotes Kras Over-activation; OBESITY-RELATED INFLAMMATION PROMOTES PANCREATIC CANCER DEVELOPMENT; POTENTIAL TARGETS FOR INTERVENTIONS; CONCLUSION; LIST OF/ACRONYMS AND/ABBREVIATIONS; REFERENCES; 6

Activation of Ras by Post-Translational Modifications ; INTRODUCTION; POST-TRANSLATIONAL MODIFICATIONS/OF RAS; Prenylation; The CAAX Processing; The Enzymes for Prenylation; Farnesyltransferase; Geranylgeranyltransferase Type I

Ras Converting Enzyme 1Isoprenylcysteine Carboxyl Methyltransferase; Targeting Ras Prenylation; Palmitoylation and/De-palmitoylation/Cycle; Phosphorylation; Ubiquitination; Acetylation; S-Nitrosylation; Bacterial Toxins and Exoenzymes; CONCLUSIONS; LIST OF/ACRONYMS AND ABBREVIATIONS; ACKNOWLEDGMENT; REFERENCES; 7

Cross Talk Between Snail and Mutant K-Ras Contributes to Pancreatic Cancer Progression ; INTRODUCTION; K-RAS AND PANCREATIC CANCER PROGRESSION; EPITHELIAL-TO-MESENCHYMAL TRANSITION AND PANCREATIC CANCER PROGRESSION

Notes:

Includes bibliographical references and index.

Electronic reproduction. Amsterdam Available via World Wide Web.

Description based on online resource; title from digital title page (viewed on September 21, 2016).

Local Notes:

Acquired for the Penn Libraries with assistance from the Dr. D. Sergeant Pepper Memorial Fund.

ISBN:

9780128035412

0128035412

Publisher Number:

99968808988

Access Restriction:

Restricted for use by site license.