Ebola virus disease : from origin to outbreak / Adnan I Qureshi.

Format:

Book

Author/Creator:

Qureshi, Adnan I., author.

Contributor:

Saeed, Omar.

Language:

English

Subjects (All):

Ebola virus disease.

Hemorrhagic Fever, Ebola--epidemiology.

Disease Outbreaks.

Epidemics--prevention & control.

Communicable Disease Control--organization & administration.

Medical Subjects:

Hemorrhagic Fever, Ebola--epidemiology.

Disease Outbreaks.

Epidemics--prevention & control.

Communicable Disease Control--organization & administration.

Genre:

Electronic books.

Physical Description:

1 online resource

polychrome

Place of Publication:

London : Academic Press, [2016]

System Details:

text file

Summary:

Ebola Virus Disease: From Origins to Outbreak covers Ebola virus disease in its entirety from its origins through major outbreaks in the past to the present day outbreak. It contains information on the West Saharan response to Ebola as well as highlights from the field in West Africa from Dr. Qureshi and Dr. Chughtai, helping to solve the primary question of what's next and aiding in formulating a path forward. With a growing awareness of the devastating effects of this viral disease and an influx of topical research, this book provides the information the global community of researchers, clinicians and students need to better inform their research and study of Ebola virus disease.

Contents:

1 Ebola Virus: Nature's Experiment Gone Wrong

The first global pandemic 2

Mankind vulnerable no more? 3

And then came Ebola virus pandemic 4

References 6

2 A Personal Journey

Arrival in Conakry, Guinea 7

Tour to Ebola virus disease isolation units 11

A visit to the villages 17

Time to bid farewell 19

Return home and the cold welcome 20

Final thoughts 21

References 22

3 Ebola Virus: The Origins

The history of Ebola virus disease outbreaks 23

Marburg virus disease emergence (1967-1975) 25

Ebola virus disease in Sudan and Zaire (1976-1977) 25

Ebola virus disease outbreak in nonhuman primates in Cote D'Ivoire (1994) 29

Ebola virus disease in Gabon (1994-1996) 29

Ebola virus disease in the Democratic Republic of Congo (1995) 30

Ebola virus disease in Uganda (2000-2001) 33

Sporadic occurrences of the Ebola virus disease 34

Case fatality differences between Ebola virus disease epidemics 34

References 36

4 Ebola Virus Disease Epidemic in Light of Other Epidemics

Common features of epidemics 40

Spanish flu epidemic (1918-1920) 41

Spanish flu and Ebola virus disease pandemics 42

Finding the culprit behind the pandemic 43

Development of vaccines and the quagmire of pseudovaccines 44

Role of general preventive strategies 46

Encephalitis lethargica (von Economo's encephalitis) epidemic (1915-1926) 47

Ebola-lrke hemorrhagic fevers in Mexico 49

The epidemic of Cocoliztli in 1576 50

How Cocoliztli differed from other major diseases 53

Epidemics in modern times 53

Severe acute respiratory syndrome (SARS) in Southeast Asia 53

"A walk through the course of the SARS epidemic" 54

Factors that promoted the global spread of SARS 56

Steps that were effective in control of SARS epidemic 56

Preventive and control measures in China 56

Preventive and control measures in Hong Kong 56

Dengue fever in Asia and South America 57

Transmission and spread of Dengue fever 57

Global burden of Dengue fever 58

The story of quarantine 58

Symbols of quarantine 59

Global faces of quarantine 60

Early American quarantine 61

Late nineteenth century 62

Public Health Service Act 62

Reorganization and expansion 62

From the inspection to intervention 62

Social implications of quarantine 62

References 63

5 Most Recent Outbreaks 2014

Ebola virus disease outbreak: Guinea 2013-2014 67

Ebola virus disease outbreak: Liberia 2013-2014 69

Ebola virus disease outbreak: Sierra Leone 2013-2014 70

Ebola virus disease outbreak: Senegal, Nigeria, and Mali (2013-2014) 71

International spread of Ebola virus disease 2014 72

References 72

6 West Saharan Response to Ebola Virus Disease Epidemic

A small village 75

The radio's last broadcast 76

During the deadly march we find heroes 77

No country will be Ebola virus-free 80

Burn their mattresses, burn their things! 82

Burn them at the stake! 83

The United States and Europe standby 85

Too late, too little to be effective 87

Our doors are open; come take our sick 90

References 91

7 Ebola Virus Disease in the United States

July 2014: first response to African outbreaks 95

August 2014: Ebola virus strikes a United States citizen 96

September 2014: the number of patients in the United States increases 96

October 2014: gaps in the United States health system 98

November 2014: Ebola virus disease reaches its first peak 100

The national response teams step up efforts for recognition and prevention 101

References 102

Structure and Genetics of Ebola Virus Disease

Evolution in our understanding of viruses 105

Understanding the genetic material (nucleic acids) 107

Structure of viruses 107

Virus and host cell 108

Ebola virus structure 109

Viral entry into the host cell 111

Ebola virus transcription 111

The body's immune system 112

White blood cells 112

Interferon production 112

Ebola virus messing with the body's immune response 113

Disruption of blood vessels and virus entry into the tissue 113

The futile leukocyte chase 113

Summary 114

References 114

9 Clinical Manifestations and Laboratory Diagnosis of Ebola Virus Infection

A typical case of Ebola virus disease 117

Ebola virus infection and spread within the body 120

Incubation period 122

Clinical manifestations 122

Laboratory diagnosis of Ebola virus infection 125

Ancillary laboratory findings 126

Factors predicting survival or death after Ebola virus infection 127

Viral persistence 127

Convalescence or recovery period 127

CDC guidelines 127

Further evaluation 128

Biosafety and biosecurity considerations with Ebola virus disease 129

Principles of personal protective equipment 131

Handling of biological specimens suspected of containing Ebola virus 132

Guidelines for the handling of laboratory specimens from suspected or laboratory confirmed Ebola virus disease patients 133

Biosafety recommendations for laboratories conducting diagnostic testing for Ebola virus disease with appropriate BSL-3/BSL-4 facilities 135

Biosafety recommendations for laboratories conducting diagnostic testing for Ebola virus disease without appropriate BSL-3/BSL-4 facilities 135

References 136

10 Ebola Virus Disease: Psychological and Social Aspects

The psychological stress and response 140

Psychological stress and manifestations in acute period 140

Psychological stress and manifestations in postinfectious period 141

Health-care response 142

Escalation by media 143

Response of officials and spoke persons, and public rituals 143

The health-care workers and caregivers 144

Acceptance into the society 145

Interaction of health-care workers with society 147

Violent behaviors within society 147

Social stigma in the United States 147

Conclusion 149

References 154

11 Treatment of Ebola Virus Disease: Therapeutic Agents

The evolution of antiviral agents 159

Antiviral agents for Ebola virus 160

Vaccines 162

Challenges to vaccine development: lessons from malaria and HIV infection 162

Antibodies from Ebola virus disease survivors 164

Antibodies made from other organisms 165

References 166

12 Ebola Virus: Natural Reservoirs

Zoonotic contribution to the new world epidemics 168

Linking Ebola virus disease to animal hosts 168

Ebola virus disease and nonhuman primates: carriers or victims? 169

Ebola virus disease and bats 171

Campaign against African bushmeat 174

References 175

13 Economic and Political Impact of Ebola Virus Disease

Direct and indirect economic consequences of Ebola virus disease epidemic 180

The impact of Ebola virus disease on various economic sectors 181

Overall fiscal impacts 183

Financial aid in progress 184

The effect of outbreak on surrounding countries' economies 185

Pregnancies and childbirths: long-term economic consequences 186

Political impact of the Ebola virus disease outbreak 187

Introduction 187

Political impact of Ebola virus disease on West African countries 188

Political impact of Ebola virus disease in the United States of America 189

References 190.

Notes:

Online resource; title from PDF title page (EBSCO, viewed January 14, 2016)

Includes bibliographical references and index.

Other Format:

Print version: Qureshi, Adnan I. Ebola virus disease : from origin to outbreak.

ISBN:

9780128042427

0128042427

0128042303

9780128042304

OCLC:

934626628

Access Restriction:

Restricted for use by site license.