Allergy, immunity and tolerance in early childhood : the first steps of the atopic March / Ulrich Wahn and Hugh A. Sampson, [editors].

Format:

Book

Contributor:

Wahn, U. (Ulrich), editor.

Sampson, Hugh A., editor.

Language:

English

Subjects (All):

Allergy in children.

Developmental immunology.

Immunity.

Genre:

Electronic books.

Physical Description:

1 online resource

polychrome

Place of Publication:

London : Academic Press, an imprint of Elsevier, [2015]

System Details:

text file

Summary:

Atopic diseases including asthma, allergic rhinitis and atopic dermatitis, as well as food allergies, have developed into major health problems in most parts of the world. The natural history of these diseases has been extensively studied including their major genetic, environmental and lifestyle determinants, as well as potential protective factors. Allergy, Immunity and Tolerance in Early Childhood: The First Steps of the Atopic March addresses these chronic disorders. Early manifestations, of these atopic disorders present a challenge to pediatric allergists and provide them with an opportunity to intervene early, aiming at primary or secondary prevention. This book unites key experts in the field from all over the world, summarizing current knowledge of the early stage of the "atopic march," as well as providing novel ideas for potential options for prevention. Summarizes the current knowledge of the epidemiological, genetic and cellular basis of allergic diseases, Represents a landmark in the field of immunology and allergy development, Fulfills the need for a book that focuses on primary and secondary allergy prevention, especially during the first years of life Book jacket.

Contents:

Front Cover; Allergy, Immunity and Tolerance in Early Childhood: The First Steps of the Atopic March; Copyright; Contents; List of Contributors; Introduction; 1 - The Maturation of Immune Function in Pregnancy and Early Childhood; Introduction; Immune development in health and disease; Early life immune regulation; Interplay of innate and adaptive immune regulation in organ-specific responses; Key influences and determinants of early immune function and regulation; Genetic factors; Direct effects of maternal allergy on immune maturation; Maternal environmental exposures and immune maturation;

Early postnatal exposures and immune maturationModulating early immune development to promote immune regulation; Conclusion; References; 2 - Immunological Aspects of the Atopic March; Introduction; Global inventory of the developmental pattern of allergen-specific antibody; Tentative interpretation of phases observed in the serological picture; The trends of IgE levels to allergenic sources; Immunoglobulin E trends examined at a molecular level; Discussion; References; 3 - Atopic Dermatitis in Infancy and Childhood; Definition; Family history and genetics; Natural history of disease;

Allergic sensitization and allergy as comorbidityRhinitis and asthma as comorbidity; Urticaria as comorbidity; Determinants of the disease; Socioeconomic status; Infant feeding; Domestic environment; Key elements of treatment; Prevention; Long-term outcome in adulthood; References; Further reading; 4 - Adverse Reactions to Food; Clinical presentation of food allergy in infancy; Epidemiology and natural course; Pathogenesis; Diagnostic; Therapy; Immunotherapy for food allergy; References; Further reading; 5 - Viral-Induced Wheeze and Asthma Development; Introduction;

Longitudinal studies of childhood wheezingEtiology of wheezing illnesses in infancy; Risk factors for virus-induced wheezing; Progression from virus-induced wheezing to asthma; Do severe viral respiratory infections in infancy cause asthma?; Conclusions; References; 6 - Infantile Lung Function and Airway Hyperresponsiveness; Introduction; Lung development; Lung function measurements; Lung function development; Postnatal impact on lung function development; Factors that may influence in utero lung function development; Infantile AHR; Summary and conclusion; References;

7 - The Development of Allergic Rhinitis in ChildhoodIncidence; Period prevalence; Sex differences; Comorbidity; The role of sensitization; Early predictors; Protective factors; Principles of therapy; Options for prevention; References; Further reading; 8 - Genes and Atopic Phenotypes; Introduction; Tools for disentangling the genetics of atopy; Do genes co-associated with multiple childhood atopy phenotypes represent atopic march candidate genes?; Summary and conclusions; References; 9 - Epigenetic Factors Before and After Birth; Introduction; Principles of epigenetic mechanisms.

Notes:

Includes bibliographical references and index.

Online resource; title from PDF title page (EBSCO, viewed September 22, 2015).

Other Format:

Print version: Wahn, Hans Ulrich Allergy, Immunity and Tolerance in Early Childhood : The First Steps of the Atopic March

ISBN:

9780127999302

0127999302

OCLC:

921142709

Access Restriction:

Restricted for use by site license.