Genetic control of malaria and dengue / edited by Zach N. Adelman.

Format:

Book

Contributor:

Adelman, Zach N., editor.

Language:

English

Subjects (All):

Mosquitoes as carriers of disease.

Malaria--Prevention.

Malaria.

Dengue--Prevention.

Dengue.

Genetic engineering.

Genre:

Electronic books.

Physical Description:

1 online resource

polychrome

Place of Publication:

London : Academic Press is an imprint of Elsevier, [2015].

System Details:

text file

Summary:

Includes coverage of vectorial capacity, critical to understanding vector-borne disease transmission, Provides a summary of the concepts of both population suppression and population replacement, Contains pivotal coverage of ethical and ecological ramifications of genetics-based control strategies, Genetic Control of Malaria and Dengue focuses on the knowledge, technology, regulation and ethics of using genetically modified mosquitoes to interrupt the transmission of important vector-borne diseases including Malaria. It contains coverage of the current state of knowledge of vector-borne diseases and how they are currently controlled; vaccine, drug and insecticide development; various strategies for altering the genome of mosquitoes in beneficial ways; and the regulatory, ethical and social environment concerning these strategies. For more than five decades, the prospect of using genetically-modified mosquitoes to control vector-borne disease transmission has been a purely hypothetical scenario. We simply did not have the technology or basic knowledge to be able to do it. With the explosion of field trials and potential interventions in development, Genetic Control of Malaria and Dengue provides a comprehensive overview of research in genetics, microbiology, virology, and ecology involved in the development and implementation of genetic modification programs for virus and disease control. This book is meant to provide a practical guide to researchers, regulators and the general public about how this technology actually works, how it can be improved, and what is still unknown. Book jacket.

Contents:

Front Cover; Genetic Control of Malaria and Dengue; Copyright Page; Contents; List of Contributors; Biography; Chapter 1; Chapter 2; Chapter 3; Chapter 4; Chapter 5; Chapter 6; Chapter 7; Chapters 8, 13; Chapter 9; Chapter 10; Chapter 11; Chapter 12; Chapter 14; Chapter 15; Chapter 16; Chapter 17; Chapter 18; Chapter 19; 1 Transgenic Pests and Human Health: A Short Overview of Social, Cultural, and Scientific Considerations; Introduction; Current State of GMOs; Dengue Fever and Malaria; Dengue Fever; Malaria; Dengue and Malaria Control;

Things to Consider Before Implementing GMO Control MethodsAllocating Resources Between Treatment and Control; Economic Development; Community Engagement; Values and Ethics of Control Measures; Stewardship; Animal Welfare; Justice As Fairness; Precaution; An Ethical, Cultural, and Social Framework; Regulation, Deliberation, and Public Communication of Biotechnology; Current US Regulation of Biotechnology; Biotechnology and the Public Sphere; Models of Public Communication; Public Opinion of Transgenics; Conclusions; Acknowledgments; References; 2 Concept and History of Genetic Control;

IntroductionAgricultural Applications of Genetic Control Lead the Field; Eradication of the New World Screwworm Fly Cochliomyia hominivorax Using the Sterile Insect Technique; Use of Genetic Sexing Strains in Mediterranean Fruit Fly SIT Programs; The Australian Sheep Blowfly (Lucilia cuprina) Field Female Killing Strains; The Current State of Using SIT to Control Agricultural Pests; Attempts to Extend Genetic Control to Mosquitoes; Progress Without Modern Biotechnology; Cytoplasmic Incompatibility and Wolbachia Population Replacement; Classical SIT; Chromosome Rearrangements;

Population Replacement Without TransgenesisModern Biotechnology Attempts to Cover the Achilles Heel of Mosquito SIT; Increasing Suppression Leveraging Larval Competition; Paratransgenesis Using Transgenic Symbionts; Population Replacement with Factors Detrimental to Mosquitoes; Population Replacement with Beneficial Factors; Acknowledgments; References; 3 Considerations for Disrupting Malaria Transmission in Africa Using Genetically Modified Mosquitoes, Ecology of Anopheline...; Malaria in Africa: Current Situation; Malaria Vectors in the African Region;

Malaria Parasites and Their Public Health SignificanceCurrent Approaches for Malaria Vector Control; Biological and Ecological Considerations for GM Release and Monitoring; Operational Considerations and Capacity Building in Africa; References; 4 Ecology of Malaria Vectors and Current (Nongenetic) Methods of Control in the Asia Region; Malaria Risk in the South East Asia Region; Ecology of Common Malaria Vectors; Anopheles culicifacies; Anopheles fluviatilis; Anopheles stephensi; Anopheles dirus; Anopheles minimus; Current (Nongenetic) Methods of Vector Control; Indoor Residual Spraying.

Notes:

Includes index.

Online resource; title from PDF title page (ScienceDirect, viewed October 28, 2015).

Other Format:

Print version: Adelman, Zach N. Genetic Control of Malaria and Dengue

ISBN:

9780128004050

0128004053

OCLC:

925521989

Access Restriction:

Restricted for use by site license.