Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia / edited by Masahiro Kizaki.

Format:

Book

Contributor:

Kizaki, Masahiro, editor.

SpringerLink (Online service)

Language:

English

Subjects (All):

Medicine.

Hematology.

Oncology.

Physical Description:

1 online resource (VIII, 193 pages 26 illustrations, 20 illustrations in color.)

Edition:

First edition 2016.

Contained In:

Springer eBooks

Place of Publication:

Tokyo : Springer Japan : Imprint: Springer, 2016.

System Details:

text file PDF

Summary:

Covering the history of breast cancer, theory of radiofrequency ablation (RFA), resection of carcinoma, imaging before and after non-surgical ablation therapy and quality of life, this book focuses on extensive breast-conserving treatment for the preservation of a cosmetically acceptable breast. It investigates the feasibility of percutaneous, minimally invasive techniques to ablate breast tumors and several modalities such as cryosurgery, laser ablation, thermoablation and high-intensity focused ultrasound. Non-surgical Ablation Therapy for Early-stage Breast Cancer centers on RFA and provides insights into cryoablation and focused ultrasound surgery. RFA has been shown to be effective for treating tumors in many types of tissue, including liver, bone, brain, kidney, pancreas and prostate. As such this book is a valuable resource for breast and general surgeons, radiation oncologists and medical oncologists in all areas. The extensive discussions enable scholars to gain radiological expertise and a basic understanding of molecular biology, leading to better surgery without scalpels.

Contents:

1. Identification and Biology of CML Stem Cells.- 2. Molecular Mechanisms of CML Stem Cell Maintenance

3. Roles for Signaling Molecules in the Growth and Survival of CML Cells.- 4. Goal of CML Treatment in the Tyrosine Kinase Inhibitor Era.- 5. Biomarkers for Determining the Prognosis of CML

6. Updated European Leukemia Net Recommendations for the Management of CML

7. Optimal Monitoring of CML Treatment: Molecular and Mutation Analysis

8. Recommendations for Management of CML in the Era of Second-Generation TKIs

9. Role of New TKIs and Combinations with Interferon-α for the Treatment of CML

10. Safety Profiles of First-Line TKIs and Managing Adverse Effects

11. Molecular Mechanism of TKI Resistance and Potential Approaches to Overcome Resistance

12. Discontinuation of Therapy and Treatment-Free Remission in CML.

Other Format:

Printed edition:

ISBN:

9784431557142

Access Restriction:

Restricted for use by site license.