Medullary Thyroid Carcinoma : Biology - Management - Treatment / edited by Friedhelm Raue.

Format:

Book

Contributor:

Raue, F. (Friedhelm), editor.

SpringerLink (Online service)

Series:

Recent results in cancer research 0080-0015 ; 204.

Recent results in cancer research

Language:

English

Subjects (All):

Medicine.

Human genetics.

Nuclear medicine.

Endocrinology.

Oncology.

Physical Description:

1 online resource.

Edition:

First edition 2015.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2015.

System Details:

Mode of Access: World Wide Web.

text file PDF

Summary:

This book offers a comprehensive overview of medullary thyroid carcinoma, both in the more common sporadic form and in the familial form, multiple endocrine neoplasia (MEN) types 2A and 2B. The coverage includes, but is not limited to, molecular biology and genetics, pathology, clinical presentation, imaging techniques, surgical treatment, and follow-up. The role of calcitonin as a highly sensitive and specific tumor marker for the screening, diagnosis, and follow-up of MTC and metastatic disease is described, and the significance of other tumor markers is also considered. With regard to treatment, the use of thyroidectomy is fully discussed, including in children carrying the mutations in the RET proto-oncogene considered causative for MEN 2. Additionally, the value of tyrosine kinase inhibitors as the most effective treatment modality in patients with a large tumor burden or rapid tumor growth, or both, is explained. Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Type 2 will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.

Contents:

Thyroid C-Cell Biology and Oncogenic Transformation

Histopathology of C cells and medullary thyroid carcinoma

Epidemiology and clinical presentation of Medullary Thyroid Carcinoma

Medullary thyroid carcinoma: Imaging

Calcitonin as a Biomarker for Medullary Thyroid Carcinoma

Hereditary Medullary Thyroid Cancer, Genotype phenotype correlation

Pheochromocytomas in Multiple Endocrine Neoplasia 2

Primary hyperparathyroidism in Multiple Endocrine Neoplasia 2 Syndrome

Surgical treatment of medullary thyroid carcinoma

Long term follow up in medullary thyroid carcinoma

Use of Tyrosine Kinase Inhibitors for Treatment of Medullary Thyroid Carcinoma.

Other Format:

Printed edition:

ISBN:

9783319225425

Access Restriction:

Restricted for use by site license.