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Chromosomal Instability in Cancer Cells / edited by B. Michael Ghadimi, Thomas Ried.
Connect to full text Available online
View onlineLIBRA RC261 .R35 v.1 (1965)-v.5 (1966), v.7 (1966)-v.98 (1985), v.100 (1986)-v.121 (1991), v.123 (1991)-v.126 (1993), v.128 (1993)-v.158 (2000); v.13:2nd ed. (1976) 1969
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Holman Biotech Commons - Periodicals Per. v.159 (2002)-184,186,188-189,191-192,194-196
Mixed Availability
Levy Dental Medicine Library - Stacks RC261 .R35 149
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- Format:
- Book
- Series:
- Recent results in cancer research 0080-0015 ; 200.
- Recent results in cancer research
- Language:
- English
- Subjects (All):
- Medicine.
- Cancer--Research.
- Cancer.
- Human genetics.
- Oncology.
- Physical Description:
- 1 online resource.
- Edition:
- First edition 2015.
- Contained In:
- Springer eBooks
- Place of Publication:
- Cham : Springer International Publishing : Imprint: Springer, 2015.
- System Details:
- Mode of Access: World Wide Web.
- text file PDF
- Summary:
- This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.
- Contents:
- DNA Repair and Chromosomal Translocations
- CINcere modelling: What have mouse models for chromosome instability taught us?
- Telomere Dysfunction, Chromosomal Instability and Cancer
- Genetic Instability and Disease Prognostication
- Causes of Chromosomal Instability
- Patterns of Chromosomal Aberrations in Solid Tumors
- Yeast as Models of Mitotic Fidelity
- The diverse effects of complex chromosome rearrangements and chromothripsis in cancer development
- Consequences of aneuploidy in cancer: transcriptome and beyond.
- Other Format:
- Printed edition:
- ISBN:
- 9783319202914
- Access Restriction:
- Restricted for use by site license.
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