Molecular Oncology Testing for Solid Tumors : A Pragmatic Approach / edited by Michael Ola Idowu, Catherine Isabelle Dumur, Carleton Theodore Garrett.

Format:

Book

Contributor:

Idowu, Michael Ola, editor.

Dumur, Catherine Isabelle, editor.

Garrett, Carleton Theodore, editor.

SpringerLink (Online service)

Language:

English

Subjects (All):

Medicine.

Oncology.

Pathology.

Physical Description:

1 online resource

Edition:

First edition 2015.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2015.

System Details:

Mode of Access: World Wide Web.

text file PDF

Summary:

This text is designed to present an up-to-date practical approach to molecular testing in an easy to understand format. Emphasis is placed on molecular testing for solid tumors, while underscoring the following: i) the crucial role of pathologists in ensuring specimen adequacy for molecular testing; ii) current molecular assays/platforms (including next-generation sequencing); iii) clinical utility and limitations of biomarkers to enable effective communication with clinicians; iv) the importance of quality assurance metrics to ensure accurate and reproducible results; v) pitfalls in test interpretation (that may lead to False Positive or False Negative interpretations); vi) importance of using standard nomenclature, including exercises on variant (mutation) description; vii) regulatory affairs, coding and reimbursement. The uniqueness of this text is the use of a standardized template for each of the molecular tests being discussed followed by a discussion of relevant quality assurance issues to ensure focused and efficient presentation of information. Molecular Oncology Testing for Solid Tumors will enable readers to easily understand the Ordering, Processing, Interpretation, Reporting and the clinical Application (OPIRA) process of molecular testing or biomarkers.

Contents:

Part I. Overview of Basic Cellular Biology

1. Normal molecular biology and definition of terms

2. Pathologic changes: Chromosomes, genes, DNA, RNA and proteins

3. Standard nomenclature - introduction and brief overview

Part II. Molecular Oncology Methodology

4. General principles of Oncology testing

5. Molecular methodologies

6. General principles of validating a molecular test

Part III. Molecular testing in Solid Tumors

7. Lung and mediastinum

8. Breast

9. Head and neck (salivary glands)

10. Thyroid and parathyroid (endocrine)

11. Gastrointestinal and Pancreatobiliary

12. Soft tissue

13. Genitourinary system

14. Central Nervous System

15. Skin and adnexa

16. Common Hereditary Cancer Syndromes

Part IV. The future is here

17. Application of next generation sequencing

Part V. Quality Assurance and Regulatory affairs

18. Quality Assurance - pre-analytic, analytic and post-analytic

19. Regulatory affairs (including accreditation)

20. Coding and re-imbursement.

Other Format:

Printed edition:

ISBN:

9783319163048

Access Restriction:

Restricted for use by site license.