A Case Approach to Perioperative Drug-Drug Interactions / edited by Catherine Marcucci, Michael P. Hutchens, Erica D. Wittwer, Toby N. Weingarten, Juraj Sprung, Wayne T. Nicholson, Kirk Lalwani, David G. Metro, Randal O. Dull, Christopher E. Swide, F. Jacob Seagull, Jeffrey R. Kirsch, Neil B. Sandson.

Format:

Book

Contributor:

Marcucci, Catherine, editor.

Hutchens, Michael P., editor.

Wittwer, Erica D., editor.

Weingarten, Toby N., editor.

Sprung, Juraj, editor.

Nicholson, Wayne T., editor.

Lalwani, Kirk, editor.

Metro, David G., editor.

Dull, Randal O., editor.

Swide, Christopher E., editor.

Seagull, F. Jacob, editor.

Kirsch, Jeffrey R., 1957- editor.

Sandson, Neil B., 1965- editor.

SpringerLink (Online service)

Language:

English

Subjects (All):

Pharmacy.

Medicine.

Anesthesiology.

Critical care medicine.

Surgery.

Physical Description:

1 online resource

Contained In:

Springer eBooks

Place of Publication:

New York, NY : Springer New York : Imprint: Springer, 2015.

System Details:

Mode of Access: World Wide Web.

text file PDF

Summary:

The occurrence of deleterious or even fatal drug-drug interactions (DDIs) in the perioperative period is no longer a theoretical concern but a harrowing reality. A Case Approach to Perioperative Drug-Drug Interactions addresses the complex realm of pharmacokinetic drug interactions in an easy-to-read volume that functions as both a comprehensive clinical reference and a casebook. The book presents a summary of the core concepts of drug interactions; an organized, annotated presentation of the drug interactions most relevant to the perioperative clinician; and approximately 200 case scenarios that highlight specific drug interactions. This book fills a real void in the clinical literature and is invaluable to anesthesiologists and surgeons, and PharmDs, as well as trainees in those specialties; intensive care staff, including physicians, physician assistants, and nurses; and nurse practitioners who staff preoperative evaluation clinics. .

Contents:

Part I. Introduction to Drug-Drug Interactions

1. Let's Start at the Very Beginning: Overcoming Fear and Gaining Mastery of Drug-Drug Interactions

2. Pharmacodynamic Interactions: Core Concepts

3. Pharmacokinetic Interactions: Core Concepts

4. A Brief Treatise On The Area Under The Curve

Part II. Introduction to Drug-Drug Interactions: Brief Review of CYP450 Enzymes, UGTs, and Transporters

5. CYP2D6: Where It All Began

6. CYP2E1: The Anesthesia Enzyme

7. CYP3A4: The Workhorse

8. CYP1A2: The Switch-hitter

9. CYP2B: 2B or Not 2B?- 10. CYP2C9: The Support Crew I

11. CYP2C19: The Support Crew II

12. UGTs: Conjugating Cousins

13. The Cytochrome P450 System In Disease States-A Brief Review

PART III. Drug-Drug Interactions: Paradigms and Core Concepts

14. P-glycoprotein and OATP Transporters

15. The “Fatal” Forty

16. The Six Patterns of Pharmacokinetic Drug-Drug Interactions

17. The Problem with the Drug-Drug Interaction Software: A Procrustean Dilemma

18. Pharmacogenomics

19. The Pharmacoepidemiology of Drug Interactions: Why and How They Are Important

20. The Lawyers Can Read, Too: Case Presentations from the Courtroom

Part IV. Drug-Drug Interactions Involving Inhalational Anesthetic Agents

21. Introduction

22. That Sums It Up

23. 1+1+1+1=?

24. A Delayed Surgeon Is A “Dismayed” Surgeon?

25. Relax, It's Only Gentamicin

26. Jaundice After Surgery

27. Everybody Clear?

28. The Hemodynamic Hole

29. Alpha-2 To The Rescue But Beware Bradycardia

30. Hot Stuff!

Part V. Drug-Drug Interactions Involving Intravenous Anesthetic Agents

31. Introduction

32. How to Successfully Occlude an Intravenous Line

33. A Curious Cause of Seizures

34. Magnesium Mama And The Mad Dad

35. Dexy's Midnight Spinal

Part VI. Drug-Drug Interactions Involving Local Anesthetics

36. Introduction

37. Comfortably Numb

38. Naturally Occurring And Nasty

39. LOL-LOL: Little Old Lady-Lots of Lido

40. The Spinal Countdown

41. Are Drug-Drug Interactions The Smoking Guns of Local Anesthetic Toxicity? Smoking Gun I

42. Are Drug-Drug Interactions The Smoking Guns of Local Anesthetic Toxicity? Smoking Gun II

43. A Perfect Storm?

44. Shake Rattle and Roll

45. Hello, We Have A Patient With Acute Delirium and We Need An Urgent Psych Consult

46. Fatal Pain Relief

47. Lipid Lifesaver

Part VII. Drug-Drug Interactions Involving Opioids

48. Introduction

49. No 'Subs'titute for Sobriety

50. A Needle And The Damage Done

51. Dad's Not Having Much Pain

52. Royal Flush

53. The Worry That's Always With Us: Afternoon Nap

54. The Bawling Baby

55. Sleeping Beauty

56. Codeine Can't Do It

57. A Shuddering Interaction

58. Double Indemnity

59. Breaking the Codeine

60. The Ultimate Ultram Primer I: My Mood Is Better, But Boy Do I Hurt!

61. The Ultimate Ultram Primer II: I “Haight” Narcotics But I Hate Seizures Worse

62. The Ultimate Ultram Primer III: Tremor-dol Trigger in Serotonin Syndrome

63. Too Much of A Good Thing

Part VIII. Drug-Drug Interactions Involving Non-opioid Pain Medications

64. Introduction

65. Pining For Pete In The Pain Clinic

66. You Do Not Look Well Today, Mon Ami

67. My Headache is Gone, But My Leg Now Hurts

68. Special 'K'ase

69. Not Manic About NSAIDs

70. Keep It Capped!

71. The ACE Is Not Always High

72. When The Smoke Clears, Relaxation Disappears

73. Befuddled by Aspirin

74. You Can't Trick Us!

Part IX. Drug-Drug Interactions Involving Benzodiazepines and Other Sedatives

75. Introduction

76. The Worry That's Always With Us: Now I'm Depressed

77. The Worry That's Always With Us: Tragic But Not Rare

78. Lack of Sedation

79. A Cold Isn't Going to Slow Me Down

80. Her Patients Never Wake Up On Time

81. When Enough Is Now Too Much

82. The Distressed Daughter

83. Check Check and Double Check

84. Doggone It-The Case is Cancelled

85. Noct' Out

86. Predisposed to Doze

87. Synergistic Sedation

Part X. Drug-Drug Interactions Involving Neuromuscular Blockade Agents

88. Introduction

89. Blocked Again

90. Irreversibility Sux

91. Keep An “Ion” The Twitches

92. A Reversal of Misfortune

93. Stop Moving

94. There's Just Not Enough Roc In The World

95. Slow Sux I: A Lengthy Wake-Up Period After Electroconvulsive Therapy

96. Slow Sux II: I Remember Reviewing This For The Boards

97. Slow Sux III: Where Did the Twitches Go?

98. Weakened All Weekend

99. The Patient Who Could Not Raise Her Head

100. An Unexpected Wait

101. Diabolical Cough Syrup

Part XI. Drug-Drug Interactions Involving Antibiotics and Antifungals

102. Introduction

103. Full Stop

104. Flummoxed by the FLOX

105. Tales of Terror

106. Too Low To Go

107. A Fungal Story

108. Rejection Protection Turned Kidney Killer

109. Can't Get Well

110. Linezolid (I): Be VREy Careful

111. Linezolid (II): Hyper and Hot

112. Not Sweet At All

113. Where Did All The Sugar Go?

114. Exposed! (Part 1)

115. Exposed! (Part 2)

116. Seizures on 5 West

Part XII. Drug-Drug Interactions Involving Cardiovascular Medications

117. Introduction

118. Riding The Rollercoaster

119. A Pressing Need For Vasopressin!

120. Too Young To Die

121. A Widening Gyre

122. Misusing Mom's Meds

123. If the Patient Has No Renal Failure, Why is Her Potassium So High?

124. Prazosin and the PTSD Paratrooper

125. Nicardipine Notes

126. Hypotension Harry

127. Too Slow to Flow

128. Better Sleep But Slower Heart

129. Extreme Blood Pressure After Ephedrine: Should We Rule Out Pheochromocytoma?

130. Heart-Stopping Treatment

131. Induction Crashes: Are There Clues In the Ashes?

132. The Wakeup Call: 2AM Trauma

133. Falling Down

134. A Hidden Drug

135. I'm Listening, I'm Listening

136. Jump Start My Heart

137. The Statin Trilogy (I): 'Statin' From The Beginning

138. The Statin Trilogy (II): Tripped And Fell At The Train 'Statin'

139. The Statin Trilogy (III): Welcome To The United 'Statins' Of America

140. Be Still, My Beating Heart

141. The Nice Niece

142. Cyclo Killer: Qu'est-ce que c'est?

143. Blurry-Eyed With Rapid Heart Beats

Part XIII. Drug-Drug Interactions Involving Coagulation Modifiers

144. Introduction

145. Seize the Day

146. The Third and Final Complication

147. An Interaction With the Furniture

148. Macrolide Mishap for Little Miss Muffett

149. From Asymptomatic to Symptomatic: a Cause of Nosebleed

150. The Consequences of Not Following A Cardiac Diet

151. Clopidogrel (I): Bagel Brunch

152. Clopidogrel (II): Conferring Over The Kung Pao

Part XIV. Drug-Drug Interactions Involving Immunosuppressants, Antiemetics, and Chemotherapy

153. Introduction

154. Beaned

155. Addisonian Adjustment

156. Tea Time

157. No Fits at Uffizi

158. Quit Steroids Quit Kidneys

159. The Fall Guy (I)

160. The Fall Guy (2)

161. The Topic of the Day

162. Bounce Back

163. Call The Cath Lab!

164. The Imatinib Inquiry: A Theoretical Case (For Now)

165. A HAART-Breaking Tale

Part XV. Drug-Drug Interactions Involving Neuropsychiatric Drugs

166. Introduction

167. Phenytoin (I): Going Crazy!

168. Phenytoin (II): The Wrong Drug for the Schizophrenic

169. Dizzy and Depressed

170. The Funeral Is On Monday

171. This Antacid Is Making Me Sick!

172. Young at Heart

173. Shiver Yes, Die No

174. Clip and Dip

175. Blue Fog

176. Confiscated Contraceptives

177. Gotta Love Derm

178. Desperate for A Drink

Part XVI. Drug-Drug Interactions Involving QT Prolonging DDIs

179. Introduction

180. Delusion At Heart

181.

At Long Last

182. Metha-don't!

183. Flash Fire

184. I Am Dizzy When I Stand Up

Part XVII. Drug-Drug Interactions Involving Foods and Nutrition

185. Introduction

186. High Fat Diet (I): No Juice For The Ketotic Kid

187. Protein Huffing and Puffing

188. Salty Sam

189. A Peak Potassium Problem

190. Awake?

191. Tropical Punch Packing a Real Knockout

192. When The Fire Won't Go Out

193. Peppermint Patty

194. From Bleeding Gums to Green Thumbs- A True Story

195. Delicious but Malicious

196. I Just Can't Lick This Problem

197. Sommelier's Surprise

198. Dairy Carefully

199. Cold And Sick, Sick And Cold

200. TPN (I): A Review and Two Interactions

201. TPN (II): A Traumatic Case of Increased Metabolism

202. Skin and Bones

203. Enough to Make You Sick

204. Determined and Desperate to Diet

Part XVIII. Drug-Drug Interactions Involving Spices and Supplements

205. Introduction

206. Caffeine Crash

207. Sad Sequelae

208. The Scary Side of Ginkgo Biloba Is No Match For An Anesthesia Superstar: Seizures

209. The Scary Side of Ginkgo Biloba Is No Match For An Anesthesia Superstar: Sugar

210. The Scary Side of Ginkgo Biloba Is No Match For An Anesthesia Superstar: Subdural

211. “Khat” Unawares

212. Pain on the Plane

213. Ca va, c'est Kava

214. Summertime and the Herbals are Hot

215. Garlic I: More Than Just Bad Breath

216. Garlic II: A Girl Named Allicin

217. “Danshen” the Night Away

218. Caught Yellow-Handed

219. St. John: Not Such A Saint

220. Hearing the News.

Other Format:

Printed edition:

ISBN:

9781461474951

Access Restriction:

Restricted for use by site license.