Genomics and personalized medicine : what everyone needs to know / Michael Snyder.

Format:

Book

Author/Creator:

Snyder, Michael, Ph. D., author.

Contributor:

EBSCOhost.

Louis B. Flexner Medical Book Fund.

Language:

English

Subjects (All):

Medical genetics.

Genomics.

Precision medicine.

Genetics, Medical.

Medical Subjects:

Genetics, Medical.

Genomics.

Physical Description:

1 online resource (x, 166 pages) : illustrations

Edition:

First edition.

Place of Publication:

Oxford ; New York : Oxford University Press, 2016.

System Details:

text file

Summary:

Today genomics, part of a larger movement toward personalize medicine, is poised to revolutionize health care. Elements of genomics are already being incorporated on a widespread basis, including parental disease screening and targeted cancer treatments. With more innovations soon to arrive at the bedside, the promise of the genomics revolution is limitless. This book offers an authoritative resource on the prospects and realities of genomics and personalized medicine. As consumers are faced with additional options and more complicated decisions regarding their own health care, Snyder unpacks this some-times-opaque subject matter into clear and actionable prose. Its contents include: A practical grounding in an important and widely misunderstood science, Specific insights on how to access genomic technologies and services currently available to consumers, including those for pregnant women and patents undergoing cancer treatment, Question-and-answer format makes for easy navigation to the topics most suited to individual readers, written in clear prose by a pioneer and leader in the field Book jacket.

Contents:

1 Personalized Medicine 1

What is personalized medicine? 1

What personal factors impact our health? 2

2 Genome Fundamentals 5

What is DNA? 5

What is a genome? 7

What does the genome do? 9

How does one person's genome differ from another person's genome? 9

How do genomes of men and women differ? 12

How is the genome decoded? 13

3 An Introduction to Cancer Genetics 21

What is cancer and how does it arise? 21

How do the BRCA1 and BRCA2 genes cause cancer? 24

What are examples of other genes implicated in cancer? 25

How does genetic information help us treat cancer? 26

4 Genomics and Cancer Treatment 31

What has been learned from genome sequencing of cancer? 31

How can genome sequencing advance cancer treatment? 32

If I have cancer should I get my tumor genome sequenced? 37

Why do anticancer drugs fail and how might genomic approaches help address this issue? 39

Can genetics and genomics help detect early cancer and monitor treatment effectiveness? 41

A new approach: What is immunotherapy? 42

How can genomics be used to harness the patient's own immune system to fight cancer? 44

5 Solving Mystery Diseases 47

What is a mystery genetic disease? 47

How many Mendelian diseases are there? 49

How are genes responsible for genetic disorders identified? 50

How useful are genomic approaches to solving mystery genetic diseases? 53

Why can't most Mendelian diseases be solved? 55

6 Complex Genetic Diseases 59

What is a complex genetic disease? 59

How does complex genetics affect neurological diseases? 61

How does complex genetics affect metabolic diseases? 62

Can some diseases be both monogenic and complex? 64

7 Pharmacogenomics 67

How can your genome directly help guide drug treatments for treating disease? 67

What are other ways your DNA can guide drug treatments? 67

Are there sex differences in drug effects? 69

8 Genomics for the Healthy Person 71

How can getting your genome sequenced improve your health? 71

Can genome sequencing affect the drugs someone takes? 76

Can genetic testing be used to predict sports performance and injuries? 78

Will sequencing my genome affect my children and my relatives? 79

9 Prenatal Testing 81

How are genome sequencing technologies changing prenatal testing? 81

Can genome sequencing be used to identify other mutations, beyond chromosomal abnormalities, that might cause disease? 83

Can genetic testing be useful for choosing healthier embryos and producing designer babies? 84

10 Effects of the Environment on the Genome and Epigenetics 87

How does the environment contribute to health? 87

When did people first begin to study environmental effects? 87

When do environmental effects begin? 88

Can environmental factors directly impact the genome? 89

What is epigenetics? 89

What are some examples of environmental effects on physiology that are mediated through epigenetics? 91

What is the role of epigenetics in disease? 92

How will increased understanding of epigenetics impact health care? 92

11 Other 'Omes 95

What other 'omes are useful for medicine? 95

How can the transcriptome and proteome be useful? 96

How can the metabolome be useful? 97

How deeply can a person be analyzed? 99

12 The Personal Microbiome 101

What is the microbiome? 101

How is the microbiome studied? 102

How does the microbiome affect health? 104

How does diet affect the microbiome? 106

Can the microbiome affect other aspects of our lives? 106

Can the microbiome be altered to improve human health? 107

13 Your Immune System and Infectious Diseases 109

How does your immune system protect you? 109

How does the immune system vary among people and affect our heallh? 111

How can we analyze infectious diseases? 112

14 Aging and Health 115

Are there genetic factors underlying longevity? 115

Are there environmental factors that affect aging and longevity? 117

Does epigenetics control aging? 118

Will we someday be able to control our aging? 119

15 Wearable Health Devices 121

What other types of personal health information can be readily collected? 121

How will this information be made available to, and used by the individual? 124

16 Big Data and Medicine 125

How much data can be gathered about a single person? 125

How much data can be gathered about a group of people? 126

How can a large database assist in medical care? 127

How can Big Data guide lifestyle decisions? 130

What are the opportunities for industry in Big Data Medicine? 130

17 Delivery of Genomic Information 133

Who controls your genomic and other health information? 133

Who will deliver genomic information to you? 134

What is the role of the physician? 135

What are the implications of direct-to-consumer genomic testing? 136

18 Ethics 139

Can your genetic information be used against you? 139

What are the concerns surrounding routine (or even mandated) genetic screening? 140

What is a possible solution? 141

19 Education 143

Can we educate people to understand genomic information? 143

How do we educate physicians to understand genomic information? 144

Who else should we educate? What is the role of healthcare providers, insurers, and policy makers? 144

20 Privacy 147

Can people be identified solely from their genome sequence? 147

Will having my genome sequenced affect my family members? 148

21 Paying for Personalized Medicine 151

Who pays for genome sequencing in treating disease? 151

Who pays for genome sequencing in preventive medicine? 153

Will genome sequencing make health care cheaper? 154

Will people act on genomic information? 155

22 The Future of Personalized Medicine 157

What other technologies will be prevalent in the personalized medicine space? 157

What will the future look like? 158.

Notes:

Includes index.

Electronic reproduction. Ipswich, MA Available via World Wide Web.

Description based on print version record.

Local Notes:

Acquired for the Penn Libraries with assistance from the Louis B. Flexner Medical Book Fund.

Other Format:

Electronic version: Snyder, Michael (Michael Paul). Genomics and personalized medicine.

ISBN:

9780190234782

0190234784

Publisher Number:

99966610656

Access Restriction:

Restricted for use by site license.