Admixture Dynamics, Natural Selection and Diseases in Admixed Populations / by Wenfei Jin.

Format:

Book

Author/Creator:

Jin, Wenfei, author.

Contributor:

SpringerLink (Online service)

Series:

Springer Theses, Recognizing Outstanding Ph.D. Research,. 2190-5053

Springer Theses, Recognizing Outstanding Ph.D. Research, 2190-5053

Language:

English

Subjects (All):

Medicine.

Human genetics.

Bioinformatics.

Biomathematics.

Physical Description:

1 online resource.

Edition:

First edition 2015.

Contained In:

Springer eBooks

Place of Publication:

Dordrecht : Springer Netherlands : Imprint: Springer, 2015.

System Details:

Mode of Access: World Wide Web.

text file PDF

Summary:

In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shapinghuman susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.

Contents:

Introduction

Distribution of length of ancestral chromosomal segments in admixed genomes

Exploring population admixture dynamics via distribution of LACS

Genome-wide search for signatures of natural selection in African Americans

Complex selective forces shaping the genes underlying human diseases

Materials and Methods.

Other Format:

Printed edition:

ISBN:

9789401774086

Access Restriction:

Restricted for use by site license.