Handbook of systems biology : concepts and insights / [edited by] A.J. Marian Walhout, Marc Vidal, Job Dekker.

Format:

Book

Contributor:

Walhout, A. J. Marian, 1969-

Vidal, Marc, 1962-

Dekker, Job.

Language:

English

Subjects (All):

Systems biology--Handbooks, manuals, etc.

Systems biology.

Systems Biology.

Medical Subjects:

Systems Biology.

Genre:

Electronic books.

Handbooks and manuals.

Physical Description:

1 online resource (xiii, 538 pages) : illustrations

polychrome

Edition:

First edition.

Place of Publication:

Amsterdam ; Boston : Elsever/Academic Press, 2012.

System Details:

text file

Summary:

This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplinesIncludes the latest research developments in human and animal models to assist with translational research. Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers.

Contents:

Machine generated contents note: Section I Components of Biological Systems

1. Proteomic Analysis of Cellular Systems / Matthias Mann

2. The Coding and the Non-coding Transcriptome / Roderic Guigo

Section II Network Properties of Biological Systems

3. Interactome Networks / Marc Vidal

4. Gene Regulatory Networks / A.J. Marian Walhout

5. Analyzing the Structure, Function and Information Flow in Signaling Networks using Quantitative Cellular Signatures / Norbert Perrimon

6. Genetic Networks / Charles Boone

7. The Spatial Architecture of Chromosomes / Bas van Steensel

8. Chemogenomic Profiling: Understanding the Cellular Response to Drug / Guri Giaever

9. Graph Theory Properties of Cellular Networks / Albert-Laszlo Barabasi

Section III Dynamic and Logical Properties of Biological Systems

10. Boolean Models of Cellular Signaling Networks / Reka Albert

11. Transcriptional Network Logic: The Systems Biology of Development / Eric H. Davidson

12. Reconstruction of Genome-Scale Metabolic Networks / Nathan E. Lewis

13. Genotype Networks and Evolutionary Innovations in Biological Systems / Andreas Wagner

14. Irreversible Transitions, Bistability and Checkpoint Controls in the Eukaryotic Cell Cycle: A Systems-Level Understanding / Bela Novak

15. Phenotypes and Design Principles in System Design Space / Michael A. Savageau

16. System Biology of Cell Signaling / Ravi Iyengar

17. Spatial Organization of Subcellular Systems / Philippe I.H. Bastiaens

Section IV Systems and Biology

18. Yeast Systems Biology: Towards a Systems Understanding of Regulation of Eukaryotic Networks in Complex Diseases and Biotechnology / Stephen G. Oliver

19. Systems Biology of Caenorhabditis elegans / Ben Lehner

20. Arabidopsis as a Model for Systems Biology / Ben Scheres

21. The Role of the Circadian System in Homeostasis / John B. Hogenesch

22. Biological and Quantitative Models for Stem Cell Self-Renewal and Differentiation / Ihor Lemischka

Section V Multi-Scale Biological Systems, Health and Ecology

23. Systems Medicine and the Emergence of Proactive P4 Medicine: Predictive, Preventive, Personalized and Participatory / Nathan D. Price

24. Cancer Systems Biology: A Robustness-Based Approach / Hiroaki Kitano

25. Systems Immunology: From Cells and Molecules to a Dynamic Multi-Scale System / Shai S. Shen-Orr

26. Causal Inference and the Construction of Predictive Network Models in Biology / Eric E. Schadt

27. Social Networks, Contagion Processes and the Spreading of Infectious Diseases / Alessandro Vespignani.

Notes:

Includes bibliographical references and index.

Publisher supplied information; title not viewed.

Other Format:

Print version: Handbook of Systems Biology.

ISBN:

9780123859440

0123859441

OCLC:

819506981

Access Restriction:

Restricted for use by site license.