Induction of bone formation in primates : the transforming growth factor-beta3 / edited by Ugo Ripamonti.

Format:

Book

Contributor:

Ripamonti, Ugo, editor.

CRC Press.

Rosengarten Family Fund.

Language:

English

Subjects (All):

Transforming growth factors-beta.

Bone morphogenetic proteins.

Transforming Growth Factor beta3.

Medical Subjects:

Transforming Growth Factor beta3.

Physical Description:

1 online resource (xiii, 197 pages.)

Place of Publication:

Boca Raton, FL : CRC Press, [2016]

System Details:

text file

Summary:

The effects of the bone morphogenetic proteins (BMPs) family on bone formation are well documented, but the transforming growth factor (TGF)-beta (β) isoforms are much less studied. The product of 20 years of study, Induction of Bone Formation in Primates: The Transforming Growth Factor-beta 3 sums up editor Ugo Ripamonti's research into the osteogenic activity of the three mammalian TGF-β isoforms, particularly in primates. It explores how the mammalian TGF-β isoforms have the potential to shed light on the apparent redundancy of bone induction signaling. The book unearths the profound and important bone inductive activity of the TGF-β

Contents:

1 Introduction: The Discovery of Redundancy and the Bone Induction Prerogative of the Three Mammalian Transforming Growth Factor-β Isoforms / UGO Ripamonti Ripamonti, UGO 1

1.1 Induction of Bone Formation before Redundancy and the Discovery of the Induction of Bone Formation by the Mammalian Transforming Growth Factor-β Isoforms 1

References 10

2 Regenerative Medicine, the Induction of Bone Formation, Bone Tissue Engineering, and the Osteogenic Proteins of the Transforming Growth Factor-β Supergene Family / UGO Ripamonti Ripamonti, UGO 15

2.1 Regenerative Medicine and Bone: Formation by Autoinduction 15

2.2 Induction of Bone Formation: Osteogenesis in Angiogenesis 21

2.3 Homologous but Molecularly Different Pleiotropic Proteins of the TGF-β Supergene Family Initiate Endochondral Bone Formation 32

Acknowledgments 37

References 39

3 Rapid Induction of Bone Formation by the Transforming Growth Factor-β₃ Isoform / UCO Ripamonti Ripamonti, UCO 47

3.1 The Transforming Growth Factor-β₃ Isoform 47

3.2 TGF-β₃ Isoform and the Induction of Bone Formation in Primates 51

3.3 Coral-Derived Macroporous Bioreactors as Delivery System for the Biological Activity of the Recombinant hTGF-β₃ Isoform 56

3.4 hTGF-β₃ Master Gene and Gene Product: Transfiguration of Neoplastic Masses into Bone 68

References 70

4 Induction of Bone Formation by the Mammalian Transforming Growth Factor-βs: Molecular and Morphological Insights / Raquel Duarte Duarte, Raquel, Kurt Lightfoot Lightfoot, Kurt, Uco Ripamonti Ripamonti, Uco 75

4.1 Introduction 75

4.2 Role of TGF-β in Differentiation of Osteoblasts 77

Canonical and Noncanonical TGF Signaling in Bone Formation: Evidence from Genetic Mouse Models 79

Canonical TGF-β Signaling Pathway 79

Noncanonical TGF-β Signaling Pathways 83

TGF-β Signaling Cross Talk in Bone Formation 84

TGF-β and MAPK Signaling 84

Wnt and TGF-β Signaling 85

TGF-β and PTH Signaling 87

TGF-β and FGF 87

TGF-β and BMP Signaling Cross Talk 87

4.3 Role of TGF-β₃ in Bone Formation: Lessons from the Non-Human Primate Papio ursinus 89

4.4 Perspectives 94

References 96

5 Regeneration of Mandibular Defects in Non-Human Primates by the Transforming Growth Factor-β₃ and Translational Research in Clinical Contexts / UGO Ripamonti Ripamonti, UGO, Carlo Ferretti Ferretti, Carlo 105

5.1 Tissue Induction and Regeneration of Craniomandibulofacial Defects 105

5.2 Rapid Induction of Bone Formation by the hTGF-β₃ Osteogenic Device in Mandibular Defects of ihe Chacma Baboon (P. ursinus) 112

References 117

6 Synergistic Induction of Bone Formation by Relatively Low Doses of Transforming Growth Factor-β₁ and -β₃ in Binary Application with Recombinant Human Osteogenic Protein-1 / Uco Ripamonti Ripamonti, Uco 123

6.1 Homologous but Molecularly Different Multiple Isoforms of the TGF-β Supergene Family Initiate the Induction of Bone Formation in Primate Species 123

6.2 Tissue Morphogenesis and Synergistic Interaction by Interposed Homologous Recombinant Morphogens 126

6.3 Synergistic Induction of Bone Formation 131

6.4 Temporal Expression of Markers of Bone Differentiation by Induction: Mechanistic Insights into the Synergistic Induction of Bone Formation 137

6.5 Synergistic Induction of Bone Formation in Full-Thickness Mandibular Defects of P. ursinus 141

Acknowledgments 142

References 144

7 Induction of Periodontal Tissue Regeneration by Recombinant Human Transforming Growth Factor-β₃ with and without Myoblastic/Pericytic Stem Cells in Papio ursinus / Jean-Claude Petit Petit, Jean-Claude, Uco Ripamonti Ripamonti, Uco 149

7.1 Introduction 149

7.2 Origins 151

7.3 Periodontal Tissue Regeneration by the Osteogenic Proteins of the TGF-β Supergene Family 156

7.4 Periodontal Tissue Regeneration by Naturally Derived, Highly Purified and Recombinant Human Bone Morphogenetic Proteins 158

7.5 Induction of Periodontal Tissue Regeneration by Recombinant Human TGF-β₃ in P. ursinus 173

7.6 Challenges and Perspectives in Regenerative Medicine of the Periodontal Tissues by the hTGF-β₃ Isoform 178

References 184.

Notes:

Electronic reproduction. Boca Raton, FL Available via World Wide Web.

Description based on print version record.

Local Notes:

Acquired for the Penn Libraries with assistance from the Rosengarten Family Fund.

ISBN:

1482216175

9781482216172

Publisher Number:

99965103589

Access Restriction:

Restricted for use by site license.