Inorganic controlled release technology : materials and concepts for advanced drug formulation / Xiang Zhang, Mark Cresswell.

Format:

Book

Author/Creator:

Zhang, Xiang, author.

Cresswell, Mark, author.

Language:

English

Subjects (All):

Controlled release technology.

Physical Description:

xiii, 249 pages : illustrations ; 24 cm

Place of Publication:

Oxford, UK : Elsevier : Butterworth-Heinemann, 2016.

Summary:

Innovative inorganic materials solutions for the controlled delivery of active pharmaceutical ingredients and therapeutic ions, Key Features, The first book on inorganic controlled release technology (iCRT), covering key aspects from chemistry, physics, synthetic methods, formulation design, characterization, and evaluation, Includes several industry-related case studies to provide practical guidance on how to use iCRT as an alternative to organic polymer systems for both future drug developments and other active ingredient applications, Demonstrates how iCRT offers an unmet business need for improved and controlled release of actives versus traditional CRT systems, which are known to have difficulty with the controlled delivery of both poorly and highly water-soluble drug compounds, Inorganic Controlled Re/ease Technology: Materials and Concepts for Advanced Drug Formulation provides practical guidance on the use and applications of iCRT to drug delivery and other healthcare applications, focussing on newly developed inorganic materials such as bioresorbable glasses and bioceramics. The use of these materials is introduced into a wide range of applications that cover inorganic drug delivery systems for new drug development and the reformulation of existing drugs. The book describes basic concepts, principles, and industrial practices by discussing materials chemistry, physics, nano/microstructure, formulation, materials processing, and case studies, as well as the evaluation and characterization of iCRT systems commonly investigated during industrial R&D. Book jacket.

Contents:

1 Materials for Inorganic Controlled Release Technology 1

1.1 Introduction 1

1.2 Comparison between Organic and Inorganic CRT 2

1.3 Materials Chemistry and Processing Technology 7

1.4 Materials Physics and Drug-Loaded Micro/Nanostructure 12

References 15

2 Materials Fundamentals of Drug Controlled Release 17

2.1 Introduction of Materials Nanostructure 17

2.2 API Distribution Within Inorganic Matrices 23

2.3 Basic Understanding of Potential Molecular Interactions 29

2.4 Theory and Practical Modelling of Drug Controlled Release Kinetics 48

References 53

Further reading 55

3 Materials Characterization of Inorganic Controlled Release 57

3.1 Introduction 58

3.2 Chemical Analysis 59

3.3 Physical Property Analysis 72

3.4 Microscopy 82

3.5 Technology for Evaluation of API and Inorganic CRT Carrying System 84

References 90

Further reading 91

4 Silica-Based Amorphous Drug Delivery Systems 93

4.1 Introduction 93

4.2 Sol-Gel Chemistry and Processing 94

4.3 Ordered Mesoporous Silica 98

4.4 Non-Ordered Porous Silica for Controlled Release 120

4.5 Porous Silica for Improved Efficacy and Tolerability of Topically Administered Active Compounds 131

References 134

5 Mesoporous Bioactive Glass-Based Controlled Release Systems 139

5.1 Introduction 139

5.2 General Synthesis Methods for Mesoporous Bioactive Glasses 140

5.3 Mesoporous Glass-Based 3D Scaffold Structures 141

5.4 The Role of MBG Surface Functionalization for Controlling Active Release 146

5.5 Case Studies 148

5.6 Conclusions and Future Context 154

References 154

6 Calcium Phosphate Materials for Controlled Release Systems 161

6.1 Calcium Phosphate Materials and Their Properties 161

6.2 Calcium Phosphate Cements 164

6.3 Calcium Phosphate Foams for Drug Delivery 178

6.4 Drug Release from Calcium Phosphate Coatings 179

References 183

7 Alternative Inorganic Systems for Controlled Release Applications 189

7.1 Introduction 189

7.2 Clays 190

7.3 Alternative Mesoporous Inorganic CRT Materials 207

7.4 Nanopartide Delivery Systems 211

References 216

8 Future Development of iCRT 221

8.1 Overview 222

8.2 Design and Development of Inorganic CRT Systems 222

8.3 Regulation and Relevant Issues 233

8.4 Summary 241

References 242

Further reading 242.

Notes:

Includes bibliographical references and index.

ISBN:

9780080999913

0080999913

OCLC:

909329996