Urea Transporters / edited by Baoxue Yang, Jeff M. Sands.

Format:

Book

Contributor:

Yang, Baoxue, editor.

Sands, Jeff M., editor.

SpringerLink (Online service)

Series:

Sub-cellular biochemistry 0306-0225 ; 73.

Sub-cellular biochemistry

Language:

English

Subjects (All):

Life sciences.

Medical genetics.

Human physiology.

Toxicology.

Biochemistry.

Cell membranes.

Physical Description:

1 online resource.

Contained In:

Springer eBooks

Place of Publication:

Dordrecht : Springer Netherlands : Imprint: Springer, 2014.

System Details:

Mode of access: World Wide Web.

text file PDF

Summary:

The mechanisms and physiological functions of urea transport across biological membranes are subjects of long-standing interest. Recent advances in the molecular biology and physiology of urea transport have yielded new insights into how and why urea moves across cell membranes. In the last two decades, seven facilitated urea transporters (UT-A1-6 and UT-B) have been cloned, and their gene organization, protein crystal structure, expression localization and physiological functions in the tissues have been described. In recent years, the studies in urea transporter knockout mouse models suggest that urea transporters may be useful targets for drug discovery of selective inhibitors. The modulation of urea transport activity by pharmacological agents may provide novel treatments for hypertension, congestive heart failure and other fluid-retaining states. However, although urea represents about 40% of all urinary solutes in normal human urine, the handling of this solute in the tissues has been largely neglected in the past, and few clinical or experimental studies now report data about urea. Most recent physiological textbooks include chapters on water and electrolyte physiology but not a single chapter on urea. Our aim in writing this book is to stimulate further research in new directions by providing novel and provocative insights into further mechanisms and the physiological significance of urea metabolism and transport in mammals. The book provides a state-of-the-art report on the latest findings on urea transport and where the field is going. Although some older work is cited, the main focus is on advances made over the past 20 years with regard to the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of urea transport in mammalian cell membranes. These aspects are especially valid, as advances in our understanding of urea transporting mechanisms and physiology promise to yield new insights into biology and medicine.

Contents:

Overview and Historical Perspective

Urea

Mathematical Modeling of Urea Transport in the Kidney

Genes and Proteins of Urea Transporters

Structure of urea transporters

Expression of Urea transporters and Their Regulation

Biochemical Properties of Urea Transporters

Transport Characteristics of Urea Transporter-B

Urea Transporter Knockout Mice and Their Renal Phenotypes.- Extrarenal phenotypes of UT-B knockout mouse

Small Molecule Inhibitors of Urea Transporters

Clinical Aspect of Urea Transporters

Active Urea Transport in Lower Vertebrates and Mammals

Urea transport Mediated by Aquaporin Water Channel Proteins.

Other Format:

Printed edition:

ISBN:

9789401793438

Access Restriction:

Restricted for use by site license.