Ras Superfamily Small G Proteins: Biology and Mechanisms 1 : General Features, Signaling / edited by Alfred Wittinghofer.

Format:

Book

Contributor:

Wittinghofer, Alfred, editor.

SpringerLink (Online service)

Language:

English

Subjects (All):

Life sciences.

Biochemistry.

Cytology.

Physical Description:

1 online resource

Contained In:

Springer eBooks

Place of Publication:

Vienna : Springer Vienna : Imprint: Springer, 2014.

System Details:

Mode of access: World Wide Web.

text file PDF

Summary:

This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.

Contents:

Evolution of the Ras Superfamily of GTPases

The structure of the G domain of the Ras superfamily

GEFs and GAPs: Mechanisms and Structures

Bacterial protein toxins acting on small GTPases

Posttranslational modifications of small G proteins

Targeting the Raf-MEK-ERK Mitogen-Activates Protein Kinase Cascade for the Treatment of RAS Mutant Cancers

RAS Genes and Cancer

The Spatial Organization of Ras Signaling

Ras Nanoclusters

Mouse Models of Ras induced Tumors and Developmental Disorders

Rap signaling

The coordinated biology and signaling partners of Ral G-proteins

Structure and Function of the mTOR Activator Rheb

Classical Rho proteins: Biochemistry of molecular switch function and regulation

Atypical Rho family members

Molecular Structures, Cellular Functions and Physiological Roles of Rho Effectors

Principles driving the spatial organization of Rho GTPase signaling at synapses

Rho GTPases in Cancer.

Other Format:

Printed edition:

ISBN:

9783709118061

Access Restriction:

Restricted for use by site license.