Amorphous Solid Dispersions : Theory and Practice / edited by Navnit Shah, Harpreet Sandhu, Duk Soon Choi, Hitesh Chokshi, A. Waseem Malick.

Format:

Book

Contributor:

Shah, Navnit, editor.

Sandhu, Harpreet (Scientist), editor.

Choi, Duk Soon, editor.

Chokshi, Hitesh, editor.

Malick, A. Waseem, editor.

SpringerLink (Online service)

Series:

Advances in delivery science and technology 2192-6204

Advances in Delivery Science and Technology, 2192-6204

Language:

English

Subjects (All):

Medicine.

Pharmaceutical technology.

Physical Description:

1 online resource.

Contained In:

Springer eBooks

Place of Publication:

New York, NY : Springer New York : Imprint: Springer, 2014.

System Details:

Mode of access: World Wide Web.

text file PDF

Summary:

This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol®, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems. Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future. .

Contents:

1 Fundamentals of Amorphous Systems: Thermodynamic Aspects

2 Theoretical Considerations in Developing Amorphous Solid Dispersions

3 Overview of Amorphous Solid Dispersion Technologies

4 Excipients for Amorphous Solid Dispersions

5 Miniaturized Screening Tools for Polymer and Process Evaluation

6 HME for Solid Dispersions: Composition and Design Considerations

7 HME for Solid Dispersions: Scale up and Late Stage Development

8 Spray Drying: Scale UP and Manufacturing

9 Design and Development of HPMCAS based spray dried dispersions

10 MBP Technology: Composition and Design Considerations

11 MBP Technology: Process Development and Scale up

12 Pharmaceutical Development of MBP Solid Dispersions: Case Studies

13 Downstream Processing Considerations

14 Structural Characterization of Amorphous Solid Dispersions

15 Dissolution of Amorphous Solid Dispersions: Theory and Practice

16 Stability of Amorphous Solid Dispersion

17 Regulatory Considerations in Development of Amorphous Solid Dispersions

18 KinetiSol® based Amorphous Solid Dispersions

19 Amorphous Solid Dispersion Using Supercritical Fluid Technology

20 Supersolubilization by Using Non-Salt Forming Acid-Base Interaction

21 Stabilized Amorphous Solid Dispersions with Small Molecule Excipients

22 Mesoporous ASD - Fundamentals

23 Mesoporous Silica Drug Delivery Systems.

Other Format:

Printed edition:

ISBN:

9781493915989

Access Restriction:

Restricted for use by site license.