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Gadd45 Stress Sensor Genes / edited by Dan A. Liebermann, Barbara Hoffman.
LIBRA Per. v.1 (1967)-v.111 (1979) v.112 (1980)-v.267 (1990), v.269 (1990)-v.330 (1993), v.332 (1993)-v.363 (1995), v.365 (1994)-v.367 (1995), v.369 (1995)-v.370 (1994), v.371B (1995), v.372 (1995)-v.373 (1995), v.375 (1995)-v.401 (1996), v.403 (1996), v.406 (1997), v.408 (1997)-v.482 (2000)-v.483 (2000)
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Mixed Availability
- Format:
- Book
- Series:
- Advances in experimental medicine and biology 0065-2598 ; 793.
- Advances in experimental medicine and biology
- Language:
- English
- Subjects (All):
- Medicine.
- Human genetics.
- Medical genetics.
- Biochemistry.
- Physical Description:
- 1 online resource.
- Contained In:
- Springer eBooks
- Place of Publication:
- New York, NY : Springer New York : Imprint: Springer, 2013.
- System Details:
- Mode of access: World Wide Web.
- text file PDF
- Summary:
- Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins). These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity. Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress. Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus. Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved. .
- Contents:
- Gadd45 in stress signaling, cell cycle control and apoptosis
- Gadd45 in Modulation of Solid Tumors and Leukemia
- Gadd45 Proteins: Key players of repair-mediated DNA demethylation
- Gadd45 proteins in Immunity
- Gadd45 in the liver - Signal transduction and transcriptional mechanisms
- The Role of the Gadd45 Family in the Nervous System: A focus on Neurodevelopment, Neuronal Injury, and Cognitive Neuroepigenetics
- Gadd45 stress sensors in preeclampsia
- Index.
- Other Format:
- Printed edition:
- ISBN:
- 9781461482895
- Access Restriction:
- Restricted for use by site license.
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