RNA Interference from Biology to Therapeutics / edited by Kenneth A. Howard.

Format:

Book

Contributor:

Howard, Kenneth A. (Kenneth Alan), editor.

SpringerLink (Online service)

Series:

Advances in delivery science and technology 2192-6204

Advances in Delivery Science and Technology, 2192-6204

Language:

English

Subjects (All):

Medicine.

Pharmaceutical technology.

Physical Description:

1 online resource.

Contained In:

Springer eBooks

Place of Publication:

Boston, MA : Springer US : Imprint: Springer, 2013.

System Details:

Mode of access: World Wide Web.

text file PDF

Summary:

The Nobel Prize winning discovery that small interfering RNA can be utilised to control cellular gene expression has propelled the field of RNA interference (RNAi) to the forefront of biomedical science as a potential molecular medicine set to revolutionalise disease treatment. Harnessing the molecular mechanisms of RNAi and development of delivery technologies is crucial for its transformation into a therapeutic modality, this dependency is the focus of “RNA Interference from Biology to Therapeutics” that gives a comprehensive overview of RNAi biology and state-of-the-art delivery methods relevant to clinical translation of RNAi therapeutics. Key players and shapers in the fields of RNAi and delivery science have been assembled in a single volume to produce a truly unique interdisciplinary text, making it a “must-read” for both students and experts in, and at the interface of, RNAi, pharmaceutical science and medicine. An attractive feature is the “future perspectives” section within each chapter that allows global leaders the opportunity to express their views on the direction the field is moving. Topics covered in the book include miRNA biology and therapeutic exploitation, exosome delivery and clinical translation. “RNA Interference from Biology to Therapeutics” is an up-to-the-minute, highly informative and invaluable text for those actively involved or interested in this fascinating and high-impact field.

Contents:

RNA Interference Pathways and Therapeutic Exploitation RNA Interference

Synthetic Dicer-Substrate siRNAs as Triggers of RNA Interference

The Role of MicroRNAs in Natural Tissue Development and Application in Regenerative Medicine

Intracellular Delivery Considerations for RNAi Therapeutics

Mucosal Delivery of RNAi Therapeutics

Nanomedicines for Systemic Delivery of RNAi Therapeutics

Lipidoids: A Combinatorial Approach to siRNA Delivery

Polymeric Micelles for siRNA Delivery

RNAi Therapeutic Delivery by Exosomes

Aptamer-Mediated siRNA Targeting

RNAi as Anti-Viral Therapy: The HIV-1 Case

Genome-Wide RNAi Screen for Identification of Human Host Factors Crucial for Influenza Virus Replication

The Application of microRNAs in Cancer Diagnostics

Therapeutic Application of miRNAs in Cancer

Clinical Development of an Inhalable Anti-RSV siRNA Treatment.

Other Format:

Printed edition:

ISBN:

9781461447443

Access Restriction:

Restricted for use by site license.