Leptin : regulation and clinical applications / Sam Dagogo-Jack, editor ; contributors Denis G. Baskin [and forty one others].

Format:

Book

Contributor:

Dagogo-Jack, Sam, 1954- editor.

Baskin, Denis G., contributor.

Language:

English

Subjects (All):

Leptin.

Genre:

Electronic books.

Physical Description:

1 online resource (299 pages) : illustrations

Place of Publication:

Cham, Switzerland : Springer, 2015.

System Details:

Mode of access: World Wide Web.

text file

Summary:

Twenty years after its discovery, recombinant human leptin has been approved by the Food and Drug Administration for the treatment of patients with lipodystrophy. Beginning with a synthesis of the vast body of work on its discovery, dissection of mechanisms, and effects in experimental models , the focus of this book shifts to a consideration of the regulation and role of leptin in humans. The emphasis on human-level data is a unique feature of this book. The results of numerous studies indicate that leptin is indeed a regulated human hormone. Leptin provides a detailed account of the myriad physiological, hormonal, metabolic, immunological, mitogenic and inflammatory modulators and targets of leptin in a single volume. Next follows a comprehensive presentation of the therapeutic trials of recombinant leptin in patients with congenital leptin deficiency, lipodystrophy, hypothalamic amenorrhea, and other emerging areas, including leptin supplementation in leptin-replete subjects, leptin substitution for insulin in diabetic models, and novel combination regimens of leptin and other biogenic peptides. Unanswered questions and future directions in leptin research are highlighted in the Foreword by Dr. Jeffrey Friedman and throughout the volume. Identifying such questions helps direct research that could deepen understanding of the complex regulation of leptin under physiological and pathological conditions, a critical prerequisite to its rational deployment in the treatment of human disorders.

Contents:

Discovery of leptin and elucidation of leptin gene expression

Leptin receptors and mechanism of action

Leptin interaction with brain orexigenic and anorexigenic pathways

Measurement of circulating leptin and soluble leptin receptors

Physiological and hormonal factors that influence leptin production

Leptin, obesity and leptin resistance

Leptin and intermediary metabolism: Focus on glucoregulation and lipid metabolism

Leptin in acute stress

Leptin and the kidney

Leptin, immune function, and inflammation

Leptin and bone

Leptin, cell cycle, and cancer

Leptin, the autonomic nervous system, and hypertension

Dynamic leptin secretion in obesity and diabetes

Leptin therapy of congenital leptin deficiency

Leptin therapy in people with normal leptin gene

Leptin therapy in patients with lipodystrophy and syndromic insulin resistance

Leptin therapy in women with hypothalamic amenorrhea

Leptin therapy as a substitute for insulin replacement in experimental models of diabetes: Clinical implications in humans

Novel combinatorial therapies involving leptin: Opportunities for mechanistic advances and therapeutic translation in human diseases.

Notes:

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed December 12, 2014).

ISBN:

9783319099156

3319099159

3319099140

9783319099149

OCLC:

898999956

Access Restriction:

Restricted for use by site license.