Behçet's disease : from genetics to therapies / Yoshiaki Ishigatsubo, editor.

Format:

Book

Contributor:

Ishigatsubo, Yoshiaki, editor.

Language:

English

Subjects (All):

Behçet's disease--Genetic aspects.

Behçet's disease.

Behçet's disease--Diagnosis.

Behçet's disease--Treatment.

Diagnosis.

Genre:

Electronic books.

Physical Description:

1 online resource (ix, 176 pages) : illustrations

Place of Publication:

Tokyo : Springer, 2015.

System Details:

Mode of access: World Wide Web.

text file PDF

Summary:

This book, besides reviewing basic and clinical aspects of Behėt's disease, covers the latest findings, including genetic studies and treatment with biologics for the disease. Although the cause of Behėt's disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis of the disease. In addition to basic research, the beneficial efficacy of anti-TNF-alpha monoclonal antibodies has also been suggested for not only uveitis associated with the disease but also other subtypes of the disease such as entero-, vasculo-, and neuro- Behėt's disease. Behėt's Disease: From Genetics to Therapies provides essential information both for basic researchers working in the fields of immunology, inflammation, and genetics, and for clinical physicians who are interested in Behėt's disease, such as ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.

Contents:

1. Overview

2. The Immunopathology of Behcet?s Disease

3. Genetics

4. Ocular Involvement

5. Vascular Involvement of Behėt?s Disease

6. Neurological Involvement

7. Gastrointestinal Involvement

8. Mucocutaneous Manifestations

9. Perspective .

Notes:

Includes index.

Online resource; title from PDF title page (SpringerLink, viewed February 19, 2015).

ISBN:

9784431544876

4431544879

4431544860

9784431544869

OCLC:

897810273

Access Restriction:

Restricted for use by site license.