Raynaud's phenomenon : a guide to pathogenesis and treatment / Fredrick M. Wigley, Ariane L. Herrick, Nicholas A. Flavahan, editors.

Format:

Book

Contributor:

Wigley, Fredrick M., editor.

Herrick, Ariane L., editor.

Flavahan, Nicholas A., editor.

Language:

English

Subjects (All):

Raynaud's disease.

Raynaud's disease--Treatment.

Genre:

Electronic books.

Physical Description:

1 online resource (xix, 394 pages) : illustrations

Place of Publication:

New York, NY : Springer, 2015.

System Details:

Mode of access: World Wide Web.

text file

Summary:

Raynaud's Phenomenon: A Guide to Pathogenesis and Treatment comprehensively reviews the understanding of a disorder that continues to challenge primary care clinicians and specialists alike. In the last decade, there have been important advances not only in understanding the pathophysiology of Raynaud's Phenomenon (RP), but also in developing diagnostic methods and effective drug and non-drug therapies. Thoroughly discussing the various manifestations of RP, including childhood RP, RP secondary to connective tissue disease, and a variety of other associated disorders that include vascular per.

Contents:

Foreword: United Kingdom; Foreword: United States of America; Preface; Acknowledgments; Contents; Contributors; 1: Historical Perspective of Raynaud's Phenomenon; Key Points; Milestones; Pathogenetic Mechanisms; Epidemiology; Diagnosis; Treatment; Conclusion; References; 2: Definition, Nomenclature, and Diagnostic Criteria; Key Points; Definition; Nomenclature; Criteria for Classification; Diagnostic Criteria; Summary; References; 3: Epidemiology of Raynaud's Phenomenon; Key Points; Primary RP; Incidence and Prevalence of Primary RP; Risk Factors for Primary RP; Age; Female Sex

Environmental Factors Genetic Factors (Including for Secondary RP); Secondary RP; Incidence and Prevalence of Secondary RP; Aetiology of Secondary RP; Systemic Sclerosis; Other Autoimmune Diseases; Other Systemic Diseases; Neurologic Diseases; Drugs (Chap. 10); Occupational Exposure to Vibration (Chap. 9); Risk and Prognostic Factors for Progression to Systemic Disease; RP as Risk Factor for Digital Ischemia, Gangrene and Auto-amputation; RP as Risk Factor for Other Organ Manifestations; Morbidity and Function; Expert Opinion; Conclusions; References

4: Thermoregulation: The Normal Structure and Function of the Cutaneous Vascular SystemKey Points; Introduction; General Aspects of the Vascular System and Blood Vessel Wall; Structural and Functional Organization of the Human Cutaneous Circulation; Mechanisms Regulating Blood Flow Responses During Cold Exposure; Modulation of Sympathetic and Adrenergic Constriction; Preclinical Models; The Human Circulation; Secondary Vasomotor Mechanisms; Transient Receptor Potential (TRP) Channels; Brown and Perivascular Adipose Tissue; Gender-Dependent Changes in Cold-Induced Vasoconstriction

6: Primary Raynaud's PhenomenonKey Points; Introduction; Case History; Definition; Epidemiology; Pathogenesis; History and Examination; Investigations; Treatment; Patient Education/General Measures; Drug Treatment (Table 6.2); Other Treatments; Transition from Primary to Secondary RP; Expert Opinion; References; 7: Raynaud Phenomenon in the Pediatric Age; Key Points; Introduction; Epidemiology Including Secondary Causes; Clinical Features; History; Examination; Investigations; Nailfold Capillaroscopy in Children; Other Imaging Techniques; Predictors of Progression to CTD

Notes:

Online resource; title from PDF title page (SpringerLink, viewed November 4, 2014).

References5: Pathophysiological Regulation of the Cutaneous Vascular System in Raynaud's Phenomenon; Key Points; Introduction; Cutaneous Vascular Responses to Cold Exposure in RP; Mechanisms Contributing to Altered Vasoconstrictor Activity in RP; Sympathetic and Adrenergic Responses; Vascular Mechanisms Underlying the Characteristic Color Changes of RP; Endothelial NO; Endothelin-1 and Endothelial Exocytosis; Others; Structural Changes in Cutaneous Circulation; Endothelial to Mesenchymal Transition; Mechanism-Based Approaches to Treating the Vascular Pathogenesis of RP; References.

ISBN:

9781493915262

1493915266

OCLC:

894354448

Access Restriction:

Restricted for use by site license.