Mitosis / edited by Mitsuhiro Yanagida, Okinawa Institute of Science and Technology Graduate University, Anthony A. Hyman, Max Planck Institute of Molecular Cell Biology and Genetics, and Jonathon Pines, University of Cambridge, The Gurdon Institute.

Format:

Book

Contributor:

Yanagida, Mitsuhiro, 1941-

Hyman, Anthony A.

Pines, Jonathon

Anne and Joseph Trachtman Memorial Book Fund.

Language:

English

Subjects (All):

Mitosis.

Medical Subjects:

Mitosis.

Physical Description:

vii, 203 pages : illustrations ; 27 cm

Place of Publication:

Cold Spring Harbor, New York : Cold Spring Harbor Laboratory Press, [2015]

Summary:

Virtually every cell in a living organism contains an identical set of chromosomes thanks to mitosis, a complex process involving hundreds of proteins and regulatory steps that ensures duplicated chromosomes are segregated equally into each daughter tell when a cell divides. Errors in this process can lead to genomic instability and are associated with cancer and other diseases. Written and edited by experts in the held, this collection from Cold Spring Harbor Perspectives in Biology coven both historical and recent developments in our understanding of mitosis and its regulation. The contributors describe how sister chromatids attach to one another and to the spindle apparatus; how the spindle microtubules nucleate, elongate, pause, and shrink; and how kinetochores and centrosomes serve as anchor and control points. They also survey the biochemical machinery that coordinates the three main regulatory stages-entry into mitosis, sister chromatid separation, and mitotic exit-in both space and time. The cellular changes that occur during cytokinesis are also reviewed in detail, as are the key differences between mitosis and meiosis. This volume will serve as a valuable reference for all cell and molecular biologists interested in this dramatic phase of the cell cycle. Book jacket.

Contents:

The Role of Model Organisms in the History of Mitosis Research / Mitsuhiro Yanagida Yanagida, Mitsuhiro 1

The Biochemistry of Mitosis / Samuel Wieser Wieser, Samuel, Jonathon Pines Pines, Jonathon 15

Emergent Properties of the Metaphase Spindle / Simone Reber Reber, Simone, Anthony A. Hyman Hyman, Anthony A. 31

Chromosome Dynamics during Mitosis / Tatsuya Hirana Hirana, Tatsuya 53

The Centrosome and Its Duplication Cycle / Jingyan Fit Fit, Jingyan, Iain M. Hagan Hagan, Iain M., David M. Glover Glover, David M. 67

The Centromere: Epigenetic Control of Chromosome Segregation during Mitosis / Frederick G. Westhorpe Westhorpe, Frederick G., Aaron E. Straight Straight, Aaron E. 103

The Kinetochore / Iain M. Cheeseman Cheeseman, Iain M. 129

Cytokinesis in Animal Cells / Pier Paolo D'Avino D'Avino, Pier Paolo, Maria Grazia Giansanti Giansanti, Maria Grazia, Mark Petronczki Petronczki, Mark 147

Aurea Mediocritas: The Importance of a Balanced Genome / Gianluca Varetti Varetti, Gianluca, David Pellman Pellman, David, David J. Gordon Gordon, David J. 165

Meiosis: An Overview of Key Differences from Mitosis / Hiroyuki Ohkura Ohkura, Hiroyuki 185.

Notes:

"A subject collection from Cold Spring Harbor Perspectives in Biology."

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Anne and Joseph Trachtman Memorial Book Fund.

ISBN:

1621821358

9781621820154

1621820157

OCLC:

895030611

Publisher Number:

99963250899