Molecular neuropharmacology : a foundation for clinical neuroscience / Eric J. Nestler, Steven E. Hyman, David Holtzman.

Format:

Book

Author/Creator:

Nestler, Eric J. (Eric Jonathan), 1954- author.

Hyman, Steven E., author.

Holtzman, David M. (David Michael), 1961- author.

Language:

English

Subjects (All):

Neuropharmacology.

Molecular neurobiology.

Central Nervous System Agents--pharmacology.

Central Nervous System--drug effects.

Central Nervous System--physiology.

Central Nervous System Diseases--drug therapy.

Medical Subjects:

Central Nervous System Agents--pharmacology.

Central Nervous System--drug effects.

Central Nervous System--physiology.

Central Nervous System Diseases--drug therapy.

Physical Description:

xiv, 528 pages : illustrations (chiefly color) ; 25 cm

Edition:

Third edition.

Place of Publication:

New York : The McGraw-Hill Companies, Inc., [2015]

Summary:

Gain a Complete understanding of Nervous System Function and its Relationship to Human Neurologic Disorders Molecular Neuropharmacology first reviews the fundamental biochemistry of the functioning nervous system and then describes how nerve cells communicate with one another through numerous types of neurotransmitters involving amino acids, monoamines, neuropeptides, and neurotrophic factors, among several others. The neuropharmacology and neural circuits that underlie complex behaviors as well as major neural disorders are also discussed as are the drugs used to treat those conditions. In the final section, the authors use the concepts presented in the first two sections to explain how irregularities in the biochemistry of neuronal interactions can lead to a wide array of clinical manifestations. Features, New chapter on neuroinflammation, All chemical structure illustrations have been redrawn and improved, Fully updated to reflect the latest breakthroughs and new drugs, The most well-written and easily understood work on the subject Book jacket.

Contents:

Basic principles of neuropharmacology

Cellular basis of communication

Synaptic transmission

Signal transduction in the brain

Excitatory and inhibitory amino acids

Widely projecting systems: monoamines, acetylcholine, and orexin

Neuropeptides

Atypical neurotransmitters

Autonomic nervous system

Neural and neuroendocrine control of the internal milieu

Pain

Neuroinflammation

Sleep and arousal

Higher cognitive function and behavioral control

Mood and emotion

Reinforcement and addictive disorders

Schizophrenia and bipolar disorder

Neurodegeneration

Seizure disorders

Stroke and migraine.

Notes:

Includes bibliographical references and index.

ISBN:

9780071827690

0071827692

OCLC:

881318278