Applied Dermatotoxicology : Clinical Aspects.

Format:

Book

Author/Creator:

Maibach, Howard I.

Contributor:

Honari, Golara.

ScienceDirect (Online service)

Language:

English

Subjects (All):

Dermatitis.

Dermatotoxicology.

Photosensitivity Disorders.

Skin Diseases--chemically induced.

Local Subjects:

Dermatitis.

Dermatotoxicology.

Photosensitivity Disorders.

Skin Diseases--chemically induced.

Genre:

Electronic books.

Physical Description:

1 online resource (150 pages)

Place of Publication:

Burlington : Elsevier Science, 2014.

System Details:

text file

Summary:

Applied Dermatotoxicology: Clinical Aspects provides concise, systematic, and state-of-the-art information on the toxicological effects of substances on skin, and recent advances in dermal toxicity testing. This book specifically addresses the clinical presentations borne out of exposure to a variety of chemicals. It begins with an overview of skin biology to provide toxicologists with a basic understanding of its anatomy and physiology. Next it presents a variety of dermatotoxicological effects, as well at the toxic agents that cause them, with color photographs to illustrate these effects.

Contents:

Front Cover; Applied Dermatotoxicology: Clinical Aspects; Copyright Page; Contents; List of Contributors; Preface; 1 Skin Structure and Function; Introduction; Structure and Function; Epidermis; Dermis; Hypodermis; Skin Appendages; Skin a Route of Entry; Measuring Skin; Skin Surface pH; Sebum; Desquamation; Thickness; The Measurement of Transepidermal Water Loss; Hydration Measurement; Measurement of Vascular Perfusion; References; 2 Irritant Contact Dermatitis: Clinical Aspects; Introduction; Clinical Manifestations of Irritant Dermatitis; Irritant Reaction; Acute Irritant Dermatitis.

Delayed Acute Irritant DermatitisChronic Cumulative ICD; Chemical Burns; Special Clinical Forms of Irritant Dermatitis; Pustular and Acneiform Irritant Dermatitis; Sensory Irritation; Airborne Irritant Dermatitis; Irritant Dermatitis from Physical Factors; Summary; References; Toxicology; Introduction; Predictive In Vitro Testing; Corrosion Testing; Transcutaneous Electrical Resistance Test Method; Membrane Barrier Test Method for Skin Corrosion; Reconstructed Human Epidermis Test Method; Irritation Testing; In Vitro RhE Test Method; Predictive In Vivo Testing.

Acute Dermal Irritation/Corrosion TestingInitial Test (In Vivo Dermal Irritation/Corrosion); Confirmatory Test (In Vivo Dermal Irritation); The Draize Rabbit Skin Irritancy Test; Human Irritation Testing; Single-Application Irritation Patch Test; Repeat-Application Cumulative Irritation Patch Test; Exaggerated Exposure Irritation Tests; Use of Bioengineering Devices; References; 3 Photoirritation (Phototoxicity): Clinical Aspects; Introduction; Basic Principles of Photobiology; Mechanisms of Phototoxic Reactions; Clinical Presentations; Main Topical and Systemic Photosensitizers; Summary.

ReferencesPhototoxicity Testing; Introduction; General Considerations for Photoirritation Testing; Predictive In Vitro Testing; Screening for UV and Visible Light Absorption; Photoreactivity Testing Using Chemical Assays; Phototoxicity Tests Using In Vitro Assays; In Vitro 3T3 NRU Phototoxicity Test; Reconstituted 3D Human Skin Models; Predictive In Vivo Testing; Phototoxicity testing in human; References; 4 Allergic Contact Dermatitis: Clinical Aspects; Introduction; ACD Syndrome; Stage 1 of ACDS; Morphological Aspects; Topographical Variants; Stage 2 of ACDS; Stage 3 of ACDS.

Stage 3A of ACDSStage 3B of ACDS; ICD Versus ACD: Clinical Aspects; Topography; Timing of Evolution; Subjective Symptoms; Conclusion; Hand Eczema (Hand Dermatitis) and ACD; Various Clinical Aspects of ACD of the Hands; Overlapping of Eczematous Lesions of the Hands; Protein Contact Dermatitis; Photoallergic Contact Dermatitis; ACD: The Patch Test, First-Line Diagnostic Tool; Reading Time; Scoring Patch Test Results; Dealing with Doubtful Reactions (?+); Clinical Relevance of Patch Test Reactions; Photopatchtest; The Series of Patch Test Allergens; The Baseline (Standard) Series.

Notes:

Print version record.

Other Format:

Print version: Maibach, Howard. Applied Dermatotoxicology : Clinical Aspects.

ISBN:

9780124201996

0124201997

OCLC:

882769900

Access Restriction:

Restricted for use by site license.