Genetics and analysis of quantitative traits / Michael Lynch, Bruce Walsh.

Format:

Book

Author/Creator:

Lynch, Michael, 1951-

Contributor:

Walsh, Bruce, 1957-

Language:

English

Subjects (All):

Quantitative genetics.

Quantitative Trait, Heritable.

Genetic Techniques.

Medical Subjects:

Quantitative Trait, Heritable.

Genetic Techniques.

Physical Description:

xvi, 980 pages : illustrations ; 24 cm

Place of Publication:

Sunderland, Mass. : Sinauer, [1998]

Summary:

This first of a two-volume set on the theoretical and empirical applications of quantitative genetics focuses on the basic biology and methods of analysis of quantitative characters. The authors endeavor to develop central theoretical concepts from first principles. They also outline basic principles of complex pedigree analysis. The extensive appendices include reviews of the statistical tools used in the book. Designed for use as a textbook or a basic reference.

Contents:

Introduction

I. Foundations of Quantitative Genetics

1. An Overview of Quantitative Genetics

2. Properties of Distributions

3. Covariance, Regression, and Correlation

4. Properties of Single Loci

5. Sources of Genetic Variation for Multilocus Traits

6. Components of Environmental Variation

7. Resemblance Between Relatives

8. Introduction of Matrix Algebra and Linear Models

9. Analysis of Line Crosses

10. Inbreeding Depression

11. Matters of Scale

II. Quantitative Trait Loci

12. Polygenes and Polygenic Mutation

13. Detecting Major Genes

14. Principles of Marker-Based Analysis

15. Mapping and Characterizing QTLS: Inbred Line Crosses

16. Mapping and Characterizing QTLS: Outbred Populations

III. Estimation Procedures

17. Parent-Offspring Regression

18. Sib Analysis

19. Twins and Clones

20. Cross-Classified Designs

21. Correlations Between Characters

22. Genotype x Environment Interaction

23. Maternal Effects

24. Sex Linkage and Sexual Dimorphism

25. Threshold Characters

26. Estimation of Breeding Values

27. Variance-Component Estimation with Complex Pedigrees

App. A1. Expectations, Variances, and Covariances of Compound Variables

App. A2. Path Analysis

App. A3. Further Topics in Matrix Algebra and Linear Models

App. A4. Maximum Likelihood Estimation and Likelihood-Ratio Tests

App. A5. Computing the Power of Statistical Tests

Literature Cited

Author Index

Organism and Trait Index

Subject Index.

Notes:

Includes bibliographical references (pages 891-[948]) and indexes.

ISBN:

0878934812

9780878934812

OCLC:

37030646

Online:

Inhaltsverzeichnis Genetics and analysis of quantitative traits