Signal transduction : principles, pathways, and processes/ edited by Lewis C. Cantley, Harvard Medical School, Tony Hunter, Salk Institute for Biological Studies, Richard Sever, Cold Spring Harbor Laboratory, Jeremy Thorner, University of California at Berkeley.

Format:

Book

Contributor:

Cantley, Lewis C., editor.

Hunter, Tony, 1943- editor.

Sever, Richard, editor.

Thorner, Jeremy W., editor.

Language:

English

Subjects (All):

Cellular signal transduction.

Developmental biology.

Pathology, Molecular.

Physical Description:

xii, 452 pages : color illustrations ; 29 cm

Place of Publication:

Cold Spring Harbor, New York : Cold Spring Harbor Laboratory Press, [2014]

Summary:

"Signal transduction pathways are molecular circuits that define how cells communicate with each other and respond to their environment. This new textbook for the first time provides a comprehensive view of the subject by covering both the basic mechanisms involved and the roles of signal transduction in fundamental biological processes. It starts by describing the basic players - signals, receptors, second messengers, and effectors - before comprehensively mapping the various different signaling pathways that operate in cells. It then goes on to provide detailed descriptions of how signal transduction functions in essential processes such as cell growth and division, metabolism, sensory perception, immunity, and reproduction"-- Provided by publisher.

"This textbook provides a comprehensive view of signal transduction, covering both the fundamental mechanisms involved and their roles in key biological processes. It first lays out the basic principles of signal transduction, explaining how different receptors receive information and transmit it via signaling proteins, ions, and second messengers. It then surveys the major signaling pathways that operate in cells, before examining in detail how these function in processes such as cell growth and division, cell movement, metabolism, development, reproduction, the nervous system, and immune function"-- Provided by publisher.

Contents:

Machine generated contents note:

(preliminary)

Preface

INTRODUCTION

I. GENERAL PRINCIPLES AND MECHANISMS

1. Signals and Receptors

Carl Henrik-Heldin, Benson Lu, Ron Evans, and Silvio Gutkind

2. General Principles and Mechanisms of Protein Regulation in Signal Transduction

Michael J. Lee and Michael B. Yaffe

3. Second Messengers

Alexandra Newton and Susan Taylor

4. Signaling Networks: Computational Capabilities and Decision-making

Evren U. Azeloglu and Ravi Iyengar

II. PATHWAYS/ROAD MAPS

MAP Kinase Pathways

Deborah Morrison

PI3K-PKB/Akt Pahway Signaling

Brian A. Hemmings & David F. Restuccia

mTOR Signaling

Mathieu Laplante and David M. Sabatini

Calcium Signaling

Martin D. Bootman

AC-cAMP

Paolo Sassone-Corsi

Wnt Signaling Pathway

Roel Nusse

Hedgehog Signaling

Philip W. Ingham

Notch/APP

Raphael Kopan

TGF? /Smad

Jeff Wrana

JAK/STAT Pathway

Douglas A. Harrison

Toll-like Receptor Signaling

Kian Huat Lim and Louis Staudt

Immunoreceptor Signaling

Lawrence E. Samelson

Signaling by Nuclear Receptors -Richard Sever & Christopher K. Glass

Hippo Pathway

Kieran F. Harvey and Iswar K. Hariharan

III. SIGNALING PROCESSES

5. Signaling to the G1 Cell Cycle

Robert J. Duronio and Yue Xiong

6. Signaling Pathways that Regulate Cell Division

Nicholas Rhind and Paul Russell

7. Cell Growth and Metabolism

Patrick S. Ward and Craig B. Thompson

8. Signal Transduction and the Regulation of Cell Migration

Peter Devreotes and Rick Horwitz

9. Signaling Pathways in Cell Polarity

Luke M. McCaffrey and Ian G. Macara

10. Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning

Norbert Perrimon, Chrysoula Pitsouli, and Ben-Zion Shilo

11. Signaling in Development 2

Benjamin Neel and Senthil Muthuswarmy

12. Signaling by Sensory Receptors

David Julius and Jeremy Nathans

13. Synaptic Signaling in Learning and Memory

Mary B. Kennedy

14. Intracellular Calcium Signaling

Ivana Y. Kuo and Barbara E. Ehrlich

15. Organismal Carbohydrate and Lipid Homeostasis

D. Graham Hardie

16. Innate Immunity and Inflammation

Kim Newton and Vishva Dixit

17. Lymphocyte Activation/Behavior

Doreen Cantrell

18. Vertebrate Reproduction

Sally Kornbluth and Rafael Fissore

19. Stress Responses

Gökhan Hotamisligil and Roger J. Davis

20. Cell Death Signaling

Douglas R. Green and Fabien Llambi

21. Cancer

Joan S. Brugge

22. Subversion of Cell Signaling by Pathogens

Kim Orth and Neal Alto

Index.

Notes:

Includes bibliographical references and index.

ISBN:

9780879699017

0879699019

OCLC:

850215925