7 options
Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases / edited by Michael B. A. Oldstone, Hugh Rosen.
Holman Biotech Commons QR1 .E6 v.253 (2001)-v.363,v.367-v.371
Available
Veterinary: Atwood Library (Campus) QR181 O75 2000
Available
LIBRA v.40 (1967)-v.113 (1984), v.115 (1985)-v.203 (1995), v.205 (1996)-v.252 (2000)
Available from offsite location
Levy Dental Medicine Library - Stacks QR1 .E6 215,271
Mixed Availability
Veterinary: du Pont Library (New Bolton) QR1 .E6 280
Mixed Availability
Veterinary: Atwood Library (Campus) QR1 .E6 271
Mixed Availability
- Format:
- Book
- Author/Creator:
- Oldstone, Michael B. A., editor.
- Series:
- Current topics in microbiology and immunology 0070-217X ; 378.
- Current Topics in Microbiology and Immunology, 0070-217X ; 378
- Language:
- English
- Subjects (All):
- Medicine.
- Immunology.
- Medical virology.
- Emerging infectious diseases.
- Physical Description:
- 1 online resource : color illustration.
- Contained In:
- Springer eBooks
- Place of Publication:
- Cham : Springer International Publishing : Imprint: Springer, 2014.
- System Details:
- Mode of access: World Wide Web.
- text file PDF
- Summary:
- This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis. One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses.
- Contents:
- The organization of the sphingosine-1-phosphate signaling system
- Structural biology of the S1P1 receptor
- Chemical and genetic tools to explore S1P biology
- S1P control of endothelial integrity
- Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen
- Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule
- Sphingosine-1-phosphate and central nervous system
- RORs in autoimmune disease.
- ISBN:
- 9783319058795
- Access Restriction:
- Restricted for use by site license.
The Penn Libraries is committed to describing library materials using current, accurate, and responsible language. If you discover outdated or inaccurate language, please fill out this feedback form to report it and suggest alternative language.