MicroRNA Targeted Cancer Therapy / edited by Fazlul H. Sarkar.

Format:

Book

Author/Creator:

Sarkar, Fazlul H., 1952- editor.

Contributor:

SpringerLink (Online service)

Language:

English

Subjects (All):

Medicine.

Science.

Oncology.

Life sciences.

Physical Description:

1 online resource : color illustration

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2014.

System Details:

Mode of access: World Wide Web.

text file PDF

Summary:

Since the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes, and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs), and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research, which is covered through eighteen chapters complied in this book “MicroRNA targeted Cancer therapy”, and it is hoped that the field of miRNA research will be appreciated through critical reading of these chapters on the cutting-edge research on miRNAs.

Contents:

Preface

The therapeutic role of microRNAs in human gliomas

miRNA expression and functions in glioma and glioma stem cells

The role of miRNAs in lung cancer drug resistance and targeted therapy

The Potential Role of MicroRNA-Based Therapy for Lung Cancer Stem Cells

State of our knowledge on miRNA targeted therapy in Lung Cancer

miRNA-based Ovarian Cancer Diagnosis and Therapy

Application of microRNA in the treatment and diagnosis of cervical cancer

Overcoming Drug Resistance in Colorectal Cancer by microRNAs

MicroRNAs as novel targets in liver cancer- facing the clinical challenge

MicroRNA based therapeutic strategies for cancer: Emphasis on advances in renal cell carcinoma

Modulating microRNA expression for the therapy of pancreatic cancer

MicroRNA targeted therapy for overcoming drug resistance, reversal of EMT and elimination of cancer stem cells in prostate and pancreatic cancer.- Modulation of deregulated miRNAs for targeted therapy in thyroid cancer

miRNA-targeted therapies in the most prevalent pediatric solid tumors

Targeting Immune System Through Targeting miRNA For Cancer Therapy.- miRNA regulation of DNA damage repair proteins in cancer cells: interplay of ATM, TRAIL and miRNA

miRNA regulation of VEGF/VEGFR signaling

Systems Biology Approaches in the Design of Effective miRNA-Targeted Therapeutics. Index.

ISBN:

9783319051345

Access Restriction:

Restricted for use by site license.