Molecular Mechanisms of Angiogenesis. From Ontogenesis to Oncogenesis / edited by Jean-Jacques Feige, Gilles Pagès, Fabrice Soncin.

Format:

Book

Author/Creator:

Feige, Jean-Jacques, editor.

Contributor:

Pagès, Gilles, editor.

Soncin, Fabrice, editor.

SpringerLink (Online service)

Language:

English

Subjects (All):

Medicine.

Oncology.

Angiography.

Cardiology.

Ophthalmology.

Physical Description:

1 online resource : color illustration

Contained In:

Springer eBooks

Place of Publication:

Paris : Springer Paris : Imprint: Springer, 2014.

System Details:

Mode of access: World Wide Web.

text file PDF

Summary:

Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells,...) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable bloodproof neovessels. This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization. The book was published under the auspices of the French Angiogenesis Society. Most contributors are prominent members of this Society or international researchers who have actively contributed to the Annual Meetings of the Society.

Contents:

Emergence of Endothelial Cells During Vascular Development

Lymphatic Vascular Morphogenesis

Finding New Partnerships; The Function of Individual Extracellular Receptor Domains in Angiogenic Signalling by VEGF Receptors

Wnt/ Frizzled Signaling in the Vasculature

BMP9, BMP10 And ALK1: An Emerging Vascular Signaling Pathway With Therapeutic Applications

Apeling Signaling in Retinal Angiogenesis

Emerging Role of the Two Related Basic Helix-Loop-Helix Proteins

TAL1 and LYL1 In Angiogenesis

Hypoxia and Extracellular Matrix Remodeling

Sphingosine-1-Phosphate in Hypoxic Signaling

Reciprocal Crosstalk Between Angiogenesis and Metabolism

Endothelial Progenitor Cells and Cardiovascular Ischemic Diseases: Characterization, Functions and Potential Clinical Applications as Biomarker and Therapeutic Tools

Endothelial Cell Reactions to Oxygen: Implications For Cancer

Tumor Angiogenesis and Lymphangiogenesis: Microenvironmental Soil For Tumor Progression And Metastatic Dissemination

Angiogenesis And Invasion in Malignant Glioma: Friends or Foes?

Role of Endothelial Cells in Tumor Escape From Immunity

Tumor High-Endothelial Venules and Lymphocyte Trafficking

Post-Transcriptional Regulation of Angiogenesis Through AU-Rich Mrna Degradation: Potential Application in Cancer Therapy

Antiangiogenic Drugs in Cancer Therapy, Effect on Advanced Renal Cell Carcinoma

Anti-Angiogenic Therapies in Colorectal Cancer

Resistance to Anti-Angiogenic Treatments via Up-Regulation of Substitution Pathways

VEGF-A Splice Variants: Do They Play a Role in Tumor Responses to Anti-Angiogenic Therapies?

Progenitor Endothelial Cells as Biomarkers of Anti-Vascular Agents

Soluble Vascular Endothelial (VE)-Cadherin : Toward a Marker of Endotelial Dysfunction

The Prognostic and Predictive Value of VEGF Across Various Tumor Types.

ISBN:

9782817804668

Access Restriction:

Restricted for use by site license.