Central Functions of the Ghrelin Receptor / edited by Jeanelle Portelli, Ilse Smolders.

Format:

Book

Author/Creator:

Portelli, Jeanelle, editor.

Contributor:

Smolders, Ilse, editor.

SpringerLink (Online service)

Series:

Receptors (Series) ; 25.

The Receptors ; 25

Language:

English

Subjects (All):

Medicine.

Neurosciences.

Neurochemistry.

Physical Description:

1 online resource : color illustration.

Contained In:

Springer eBooks

Place of Publication:

New York, NY : Springer New York : Imprint: Springer, 2014.

System Details:

Mode of access: World Wide Web.

text file PDF

Summary:

The Ghrelin receptor was identified before its natural ligand ghrelin. This receptor is found both centrally and peripherally, and has been shown to affect various processes, such as food intake, gut motility, memory, glucose and lipid metabolism, cardiovascular performances, reproduction, memory, and immunological responses, amongst others. The functions of the ghrelin receptor in the central nervous system are numerous and are still being explored. In this book we specifically focus on the various roles of the ghrelin receptor in the central nervous system. In a first set of chapters, the book will focus on the discovery and the properties of this intriguing constitutively active G-protein coupled receptor, on its multiple intracellular transduction mechanisms and the various subtypes of the currently known ghrelin receptor complexes. Next, the book will elaborate on the mitochondrial mechanisms regulated by the ghrelin receptor, its role in feeding and drug addictive mechanisms, memory, sleep and arousal. The final chapters focus on the potential of this receptor as a target for the treatment of neurological disorders including Parkinson's disease, epilepsy, anxiety and depression.

Contents:

Constitutive activity of the ghrelin receptor

Homodimerization and heterodimerization of the ghrelin receptor

The role of the ghrelin receptor in appetite and energy metabolism

The vagus nerve and ghrelin function

Central Ghrelin Receptors and Food Intake

Ghrelin receptors a novel target for obesity

Ghrelin receptor antagonism as a potential therapeutic target for alcohol use disorders: a preclinical perspective

Clinical Research on the Ghrelin Axis and Alcohol Consumption

Ghrelin and Sleep Regulation

Ghrelin and Memory

Ghrelin receptors and Epilepsy

Ghrelin plays a role in various physiological and pathophysiological brain functions

Ghrelin and Parkinson's Disease.

ISBN:

9781493908233

Access Restriction:

Restricted for use by site license.